CARNITINE CONCENTRATION DURING THE DEVELOPMENT OF HUMAN-TISSUES
CARNITINE CONCENTRATION DURING THE DEVELOPMENT OF HUMAN-TISSUES
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DOI：
10.1016/0378-3782(89)90101-1
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发表时间：
1989-04-01
影响因子：
2.5
通讯作者：
TAKESHITA, K
中科院分区：
文献类型：
--
作者：
NAKANO, C;TAKASHIMA, S;TAKESHITA, K
不同的肉毒碱存储模式在发育中的人体组织（骨骼肌，肝脏和大脑）被证明。在早产期间，骨骼肌和肝脏中的肉毒碱浓度相对于其他组织高，并且骨骼肌中的肉毒碱浓度随着生长而增加。另一方面，脑肉毒碱浓度低。大脑中含有更大比例的酰基肉碱比从妊娠中期的游离肉碱，而骨骼肌和肝脏中含有更大浓度的游离肉碱比酰基肉碱。这些不同的肉毒碱浓度和组合物模式在骨骼肌，肝脏和大脑可能与成熟的潜在肉毒碱储备和代谢功能，如脂肪酸的利用和水库的乙酰单位，在每个发育组织。
The different carnitine storage patterns in developing human tissues (skeletal muscle, liver and brain) were demonstrated. The carnitine concentration was high in the skeletal muscle and liver relative to other tissues during preterm gestation, and the skeletal muscle carnitine concentration increased with growth. On the other hand, the brain carnitine concentration was low. The brain contained a larger proportion of acylcarnitine than of free carnitine from midgestation, while the skeletal muscle and liver contained larger concentrations of free carnitine than of acylcarnitine. These different carnitine concentrations and composition patterns in the skeletal muscle, liver and brain may be related to maturation of the potential carnitine reserve and to metabolic functions, such as fatty acid utilization and the reservoir of acetyl units, in each developmental tissue.