More subjects are required for ventrolateral than dorsolateral prefrontal TMS because of intolerability and potential drop-out
More subjects are required for ventrolateral than dorsolateral prefrontal TMS because of intolerability and potential drop-out
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DOI：
10.1371/journal.pone.0217826
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发表时间：
2019-06-03
期刊：
影响因子：
3.7
通讯作者：
Konishi, Seiki
中科院分区：
文献类型：
--
作者：
Han, Shuyan;Ogawa, Akitoshi;Konishi, Seiki
经颅磁刺激（TMS）的人类外侧前额叶皮层，特别是腹侧区域，往往会造成相当大的不适受试者。到目前为止，与大量的文献刺激背外侧前额叶皮层，腹外侧前额叶皮层已较少受到刺激，部分原因是一些科目是无法忍受的刺激腹外侧前额叶皮层。为了预测刺激背外侧和腹外侧前额叶皮质所需的额外受试者数量，20名年轻健康受试者报告了两个评估评分：TMS引起的不适和完成TMS实验所产生的不耐受性。单脉冲刺激（SPS）或θ脉冲串刺激（TBS）被施加到外侧前额叶皮层。使用高分辨率扩展的10-20系统来提供体素分数的准确估计。腹外侧前额叶皮层对SPS和TBS的不适感评分均高于背外侧前额叶皮层。SPS和TBS均在刺激位置F8处引起最大不适。大约一半（分别为11例和10例）的受试者无法耐受标准TMS方案下的SPS和TBS至F8。进一步计算外侧前额叶皮层中所有体素的不耐受性，这使我们能够估计特定目标区域所需的额外受试者数量。这些结果表明，受试者在刺激外侧前额叶皮层期间的不适的先验知识可以在适当数量的招募受试者的实验规划中具有实际用途，并提供可用于预测额外受试者数量的不耐受概率的数据库。
Transcranial magnetic stimulation (TMS) of the human lateral prefrontal cortex, particularly the ventral region, often causes considerable discomfort to subjects. To date, in contrast to abundant literature on stimulations to the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex has been less frequently stimulated, partly because some subjects are intolerable of stimulation to the ventrolateral prefrontal cortex. To predict the additional number of subjects required for the stimulation of the dorsolateral and ventrolateral prefrontal cortices, 20 young healthy subjects reported two evaluation scores: the discomfort caused by TMS and the resulting intolerability to complete the TMS experiments. Single-pulse stimulation (SPS) or theta-burst stimulation (TBS) was administered to the lateral prefrontal cortex. The high-resolution extended 10-20 system was used to provide accurate estimation of the voxelwise scores. The discomfort ratings with the SPS and TBS were relatively higher in the ventrolateral prefrontal cortex than those in the dorsolateral prefrontal cortex. Both the SPS and TBS elicited maximal discomfort at the stimulation position F8. The SPS and TBS to F8 under the standard TMS protocols were intolerable for approximately one half (11 and 10, respectively) of the subjects. The intolerability was further calculated for all voxels in the lateral prefrontal cortex, which enabled us to estimate the additional number of subjects required for specific target areas. These results suggest that prior knowledge of subjects' discomfort during stimulation of the lateral prefrontal cortex can be of practical use in the experimental planning of the appropriate number of recruited subjects and provide the database for the probability of intolerability that can be used to predict the additional number of subjects.