Specific metabolic rates of major organs and tissues across adulthood evaluation by mechanistic model of resting energy expenditure
Specific metabolic rates of major organs and tissues across adulthood evaluation by mechanistic model of resting energy expenditure
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DOI：
10.3945/ajcn.2010.29885
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发表时间：
2010-12-01
影响因子：
7.1
通讯作者：
Muller, Manfred J.
中科院分区：
文献类型：
--
作者：
Wang, ZiMian;Ying, Zhiliang;Muller, Manfred J.
背景Elia提出了成年人主要器官和组织的特定静息代谢率（K（1），单位为kcal kg（-1）d（-1（见《能量代谢、组织决定因素和细胞推论》，纽约，NY Raven出版社，1992年）2019 - 05 - 22 00：00本研究的目的是评价Elia的K（1）值在成年人中的适用性，并探讨年龄对K（1）值的潜在影响。设计一种新的方法，以REE = Sigma（K（1）× T（1））为机理模型，评估主要器官和组织的K（1）值。其中REE是通过间接热量测定法测量的全身静息能量消耗，T（1）是通过磁共振成像测量的单个器官和组织的质量。通过逐步单变量回归分析计算K（1）值的REE和T（1）边际95%CI。结果Elia的K（1）值在青年组和中年组均在95%CI的范围内，而Elia的K（1）值在>50岁组超出了95%CI的右界，这表明Elia的研究高估了该组的K（1）值3%。50岁时，肝脏194岁，大脑233岁，心脏和肾脏426岁，骨骼肌126岁，脂肪组织44岁，骨骼肌116岁。
Background The specific resting metabolic rates (K(1) in kcal kg(-1) d(-1)) of major organs and tissues in adults were suggested by Elia (In Energy metabolism tissue determinants and cellular corollaries New York NY Raven Press 1992) to be as follows 200 for liver 240 for brain 440 for heart and kidneys 13 for skeletal muscle 45 for adipose tissue and 12 for residual organs and tissues How ever Elia s K(1) values have never been fully evaluatedObjectives The objectives of the present study were to evaluate the applicability of Elia s K(1) values across adulthood and to explore the potential influence of age on the K(1) valuesDesign A new approach was developed to evaluate the K(1) values of major organs and tissues on the basis of a mechanistic model REE = Sigma(K(1) x T(1)) where REE is whole body resting energy expenditure measured by Indirect calorimetry and T(1) is the mass of individual organs and tissues measured by magnetic resonance imaging With measured REE and T(1) marginal 95% CIs for K(1) values were calculated by stepwise univariate regression analysis An existing data base of nonobese healthy adults [n= 131 body mass index (in kg/m(2)) 50 y (n = 37)Results Elia s K(1) values were within the range of 95% CIs in the young and middle age groups However Elia s K(1) values were outside the right boundaries of 95% CIs in the >50-y group which indicated that Elia s study overestimated K(1) values by 3% in this group Age adjusted K(1) values for adults aged >50 y were 194 for liver 233 for brain 426 for heart and kidneys 126 for skeletal muscle 44 for adipose tissue and 11 6 for residualsConclusion The general applicability of Elia s K(1) values was validated across adulthood although age adjustment is appropriate for specific applications Am J Clin Nutr 2010 92 1369-77