A simple method for the alkaline hydrolysis of esters
A simple method for the alkaline hydrolysis of esters
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DOI：
10.1016/j.tetlet.2007.09.074
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发表时间：
2007-11-12
影响因子：
1.8
通讯作者：
Ragoussis, Valentine
中科院分区：
文献类型：
--
作者：
Theodorou, Vassiliki;Skobridis, Konstantinos;Ragoussis, Valentine
A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed. (C) 2007 Elsevier Ltd. All rights reserved.
