Diminished rates of bone formation in normal black adults.
Diminished rates of bone formation in normal black adults.
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正常黑人成年人的骨形成率降低。
DOI：
10.1056/nejm198812293192603
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Bell,NH
中科院分区：
文献类型：
--
作者：
Weinstein,RS;Bell,NH
黑人比白人有更大的骨量，骨质疏松症和髋部骨折的发生率更低。我们对12名黑人（6男6女）和13名白人（8男5女）的髂嵴进行了活检，他们的年龄（范围，19 - 46岁）和体重相匹配，以确定黑人和白人之间是否存在组织形态学差异。与此相反，用四环素标记物测定的动态测量结果显示，黑人的平均骨形成率仅为白人的35%（P<0.001）。我们得出结论，黑人的骨转换率低于白人，因为骨吸收和骨形成在稳态下密切相关。如果在骨质疏松症中，先前再吸收的空腔在重塑部位的重建是不完全的，那么骨骼重塑速率的降低可以提供一种维持和保存黑人骨量的方法。（N Engl J Med 1988; 319：1698-701.）
Blacks have a greater bone mass and a lower incidence of osteoporosis and hip fractures than whites. We performed biopsies of the iliac crest in 12 blacks (6 men and 6 women) and 13 whites (8 men and 5 women) who were matched for age (range, 19 to 46 years) and weight, to determine whether histomorphometric differences between blacks and whites could be identified.The static measurements of cortical and cancellous bone architecture were not significantly different in the two groups. In contrast, the dynamic measurements, determined with tetracycline markers, showed that the mean rate of bone formation in the blacks was only 35 percent of that in the whites (P<0.001).We conclude that the rate of bone turnover is lower in blacks than in whites, since bone resorption and bone formation are closely coupled in the steady state. If reconstitution of previously resorbed cavities at remodeling sites is incomplete in osteoporosis, a reduction in the rate of skeletal remodeling could provide a means for maintaining and preserving bone mass in blacks. (N Engl J Med 1988; 319:1698–701.)