Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2
Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2
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DOI：
10.1002/hed.23716
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发表时间：
2015-08-01
影响因子：
2.9
通讯作者：
van Es, Robert J. J.
中科院分区：
文献类型：
--
作者：
Noorlag, Rob;van der Groep, Petra;van Es, Robert J. J.
研究背景基因表达谱分析显示口腔鳞状细胞癌（OSCC）淋巴结转移的预测特征。四个最具预测性的基因是分泌性白细胞蛋白酶抑制剂（SLPI）、脂质运载蛋白-2（LCN 2）、血小板反应蛋白-2（THBS 2）和肿瘤相关钙信号转导子2（TACSTD 2）。本研究相关的蛋白表达与淋巴结转移，总生存期（OS），疾病特异性生存期（DSS）。MethodsTwo百12例口腔鳞癌患者包括蛋白表达分析免疫组化severity.ResultsSLPI表达与淋巴结转移在整个队列，而不是在一个亚组的cT 1至2N 0。在多变量分析中，SLPI表达与OS（风险比[HR]=0.61）和DSS（HR=0.47）相关。LCN 2、THBS 2和TACSTD 2与淋巴结转移、OS和DSS均无相关性。结论SLPI表达与淋巴结转移相关，但对早期口腔癌淋巴结转移的判断无价值。然而，它是OS和DSS的独立预测因子，因此是OSCC的相关预后生物标志物。(c)2014 Wiley Periodicals，Inc.头颈部37：1130-1136，2015
BackgroundGene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with lymph node metastases, overall survival (OS), and disease-specific survival (DSS).MethodsTwo hundred twelve patients with OSCC were included for protein expression analysis by immunohistochemistry.ResultsSLPI expression correlates with lymph node metastases in the whole cohort, not in a subgroup of cT1 to 2N0. SLPI expression correlates with OS (hazard ratio [HR]=0.61) and DSS (HR=0.47) in multivariate analysis. LCN2, THBS2, and TACSTD2 show no correlation with lymph node metastases, OS, or DSS.ConclusionAlthough SLPI expression correlates with lymph node metastases, it has no additional value in determining lymph node metastases in early oral cancer. However, it is an independent predictor for both OS and DSS and therefore a relevant prognostic biomarker in OSCC. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 1130-1136, 2015