To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions
To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions
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DOI：
10.1002/adsc.200606018
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发表时间：
2006-05-01
影响因子：
5.4
通讯作者：
Whiting, Andrew
中科院分区：
文献类型：
--
作者：
Arnold, Kenny;Davies, Bryan;Whiting, Andrew
动力学研究表明，在相对较低的温度条件下，胺和羧酸在没有催化剂的情况下直接生成酰胺，但高度依赖于底物。结果表明，双功能催化剂表现出更大的潜力。
Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the reaction, especially for less reactive acids, and initial results indicate that bifunctional catalysts show even Greater potential.