Interferon treatment for hairy cell leukemia: an update on a cohort of 69 patients treated from 1983-1986.
Interferon treatment for hairy cell leukemia: an update on a cohort of 69 patients treated from 1983-1986.
复制标题
毛细胞白血病的干扰素治疗：1983-1986 年治疗的 69 名患者队列的最新情况。
作者：
H. Golomb;M. Ratain;R. Mick;K. Daly
本文报告了1983 ~ 1986年69例以干扰素α-2b（IFN）为主治疗的毛细胞白血病（HCL）患者的随访资料。到1991年10月的随访显示，只有11名患者死亡。完成预期的12个月或更长时间的初始IFN治疗的57例患者中有41例最终被认为是IFN失败。39例需要再次治疗（38例接受第二疗程IFN，1例接受喷司他丁）。两名患者在没有进一步治疗HCL的情况下死亡。干扰素治疗失败的中位时间为33个月。16名患者还活着，在完成最初12个月或更长时间的干扰素治疗后不需要进一步治疗。8例患者在完成第二个疗程的干扰素治疗1.3年后的中位时间接受了第三个疗程的干扰素治疗。7例患者发生了第二种恶性肿瘤，其中3例在开始干扰素治疗后3.5 - 6.5年发生了高度恶性淋巴瘤。我们的结论是，虽然干扰素提供了很好的姑息治疗，大多数患者最终将需要进一步治疗干扰素或化疗。HCL的未来试验必须意识到第二种恶性肿瘤是常见的死亡原因。
This report documents the follow-up information on 69 hairy cell leukemia (HCL) patients treated with interferon alpha-2b (IFN) as primary treatment from 1983-86. Follow-up through October 1991 shows only 11 patients have died. Forty-one of the 57 patients completing the intended 12 or more months of initial IFN treatment were eventually considered IFN failures. Thirty-nine required retreatment (38 received a second course of IFN and one received pentostatin). Two patients died without further therapy for HCL. The median time to interferon failure was 33 months. Sixteen patients are alive and have not required further treatment after completing their initial 12 or more months of interferon. Eight patients underwent a third course of interferon therapy at a median time after completion of a second course of IFN of 1.3 years. Seven patients developed a second malignancy; three of these patients developed a high-grade lymphoma between 3.5 and 6.5 years after initiation of interferon therapy. We conclude that although interferon provides excellent palliation, most patients will eventually require further treatment with interferon or chemotherapy. Future trials in HCL must be aware of second malignancies as a common cause of death.