Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
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DOI：
10.1016/j.fct.2004.07.002
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发表时间：
2004-11-01
影响因子：
4.3
通讯作者：
Bucher, JR
中科院分区：
文献类型：
--
作者：
Hooth, MJ;Sills, RC;Bucher, JR
反式肉桂醛是一种广泛使用的天然成分，作为调味剂和芳香剂添加到食品和化妆品中。将F344/N大鼠和B6 C3 F（1）小鼠暴露于饲料中的微胶囊化反式肉桂醛3个月或2年。所有研究均包括未处理组和溶剂对照组。在为期三个月的研究中，大鼠和小鼠被给予含有4100、8200、16,500或33,000 ppm反式肉桂醛的饮食。在大鼠中，所有接触组的摄食量均减少。在小鼠中，最高剂量组的摄食量减少。所有给药雄性动物的体重均低于对照组。暴露于16，500或33，000 ppm的雌性大鼠和暴露于8，200 ppm或更高浓度的雌性小鼠体重下降。所有大鼠均存活至研究结束，但最高剂量组中的一些雄性小鼠因给药饲料适口性不良导致营养不足而死亡。在暴露于8200 ppm或更高浓度的大鼠和暴露于33，000 ppm的雌性小鼠中，前胃鳞状上皮细胞增生的发生率显著增加。在小鼠中，暴露于百万分之16，500的雄性和雌性以及暴露于百万分之33，000的雌性的鼻腔嗅觉上皮变性的发生率显著增加。在为期两年的研究中，大鼠和小鼠暴露于1000，2 100或4 100 ppm的反式肉桂醛。暴露于2100 ppm的小鼠和暴露于4100 ppm的大鼠和小鼠的体重降低。在大鼠中，马尿酸排泄与剂量成比例，表明吸收、代谢和排泄未饱和。在大鼠或小鼠中，反式肉桂醛未导致肿瘤。在雄性和雌性小鼠中观察到鳞状细胞乳头状瘤和前胃癌，但发生率在NTP历史对照范围内，认为与反式肉桂醛暴露无关。爱思唯尔有限公司出版
trans-Cinnamaldehyde is a widely used natural ingredient that is added to foods and cosmetics as a flavoring and fragrance agent. Mate and female F344/N rats and B6C3F(1) mice were exposed to microencapsulated trans-cinnamaldehyde in the feed for three months or two years. All studies included untreated and vehicle control groups. In the three-month studies, rats and mice were given diets containing 4100, 8200, 16,500, or 33,000 ppm trans-cinnamaldehyde. In rats, feed consumption was reduced in all exposed groups. In mice, feed consumption was reduced in the highest dose groups. Body weights of all treated males were less than controls. Body weights were reduced in female rats exposed to 16,500 or 33,000 ppm and female mice exposed to 8200 ppm or greater. All rats survived to the end of the study but some male mice in the highest dose groups died due to inanition from unpalatability of the dosed feed. The incidence of squamous epithelia] hyperplasia of the forestomach was significantly increased in rats exposed to 8200 ppm or greater and female mice exposed to 33,000 ppm. In mice, the incidence of olfactory epithelial degeneration of the nasal cavity was significantly increased in males and females exposed to 16,500 ppm and females exposed to 33,000 ppm. In the two-year studies, rats and mice were exposed to 1000, 2 100, or 4 100 ppm trans-cinnamaldehyde. Body weights were reduced in mice exposed to 2 100 ppm and in rats and mice exposed to 4100 ppm. In rats, hippuric acid excretion was dose proportional indicating that absorption, metabolism, and excretion were not saturated. No neoplasms were attributed to trans-cinnamaldehyde in rats or mice. Squamous cell papillomas and carcinomas of the forestomach were observed in male and female mice but the incidences were within the NTP historical control range and were not considered to be related to trans-cinnamaldehyde exposure. Published by Elsevier Ltd.