CLINICAL IMMUNITY AFTER NEONATAL ROTAVIRUS INFECTION - A PROSPECTIVE LONGITUDINAL-STUDY IN YOUNG-CHILDREN
CLINICAL IMMUNITY AFTER NEONATAL ROTAVIRUS INFECTION - A PROSPECTIVE LONGITUDINAL-STUDY IN YOUNG-CHILDREN
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DOI：
10.1056/nejm198307143090203
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
LUND, JS
中科院分区：
文献类型：
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作者：
BISHOP, RF;BARNES, GL;LUND, JS
为探讨新生儿轮状病毒感染是否对新生儿轮状病毒感染具有免疫力，对81例新生儿出生时进行了临床和血清学观察。在出生的前14天，44名婴儿排泄了轮状病毒。有(55%)和无(54%)新生儿感染的婴儿在接下来的3年内有轮状病毒感染。在有新生儿感染的婴儿中，与新生儿后轮状病毒感染相关的症状明显较少，也不严重(P=0.003)。前者新生儿首次感染时有38%(9/24)有轻度(3例)或中度(6例)症状，后者有85%(17/20例)有轻度(3例)、中度(6例)或重度(8例)症状。因此，新生儿轮状病毒感染不能提供对再次感染的免疫力，但确实可以防止在再次感染期间发生临床严重疾病。
To determine whether rotavirus infection in newborn babies conferred immunity to postneonatal rotavirus infection 81 babies were studied at birth and observed clinically and serologically for 3 yr. During the first 14 days of life, 44 of the infants excreted rotavirus. Infants, with (55%) and without (54%) neonatal infection, had rotavirus infection during the next 3 yr. Symptoms associated with postneonatal rotavirus infection were significantly less frequent and less severe in the infants who had had neonatal infection (P = 0.003) than in those who had not. Of the former group, 38% (9 of 24 infants) had symptoms of mild (3 infants) or moderate (6) severity during the 1st postneonatal infection; 85% of the latter group (17 of 20 infants) had mild (3), moderate (6) or severe (8) symptoms. Thus, neonatal rotavirus infection does not confer immunity against reinfection, but does protect against the development of clinically severe disease during reinfection.