Cisplatin potentiation of radiotherapy. Long-term follow-up.
Cisplatin potentiation of radiotherapy. Long-term follow-up.
复制标题
顺铂增强放疗效果。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
N. Snyderman
中科院分区：
文献类型：
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作者：
B. Leipzig;S. Wetmore;R. Putzeys;J. Suen;N. Snyderman
33例无法手术的头颈部鳞状细胞癌患者接受了顺铂（15 mg/平方米）治疗，与大剂量放射治疗同步给药。29名患者（88%）对该方案有反应;其中20名患者的所有疾病完全消退。20人中有8人在治疗不到一年的时间内复发。在那些没有复发的患者中，随访期很短。它的结论是，临床回归反应是更有可能与这种治疗方案比单独放射治疗，这种反应可能是一个更好的姑息治疗。需要对这种治疗方式的组合进行进一步研究。
Thirty-three patients with inoperable squamous cell carcinoma of the head and neck were treated with cisplatin, 15 mg/sq m, administered synchronously with high-dose radiation therapy. Twenty-nine patients (88%) responded to the regimen; of these, 20 had complete regression of all disease. Eight of the 20 had a relapse in less than one year of their treatment. Among those patients who did not have a relapse, the follow-up period was short. It is concluded that a clinical regression response is more likely with this treatment regimen than with radiation therapy alone, and that that response may be a better palliation. Further study of this combination of treatment modalities is warranted.