The GC-SMB separation of the enantiomers of isoflurane

The GC-SMB separation of the enantiomers of isoflurane
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异氟烷对映体的GC-SMB分离

DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Morbidelli
M. Morbidelli
中科院分区：
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文献类型：
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作者：
G. Biressi;A. Rajendran;M. Mazzotti;M. Morbidelli

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本文报道了用气相色谱模拟移动床法在环糊精固定相上分离手性麻醉药异氟醚对映体的研究。实验已经进行了调查的主要操作参数，如开关时间，流速和温度的影响。该研究表明，有可能将对映异构体分离到高纯度水平以用于临床试验。还发现，与先前研究的安氟醚系统相比，分离对干扰非常敏感。
The study of separation of the enantiomers of chiral anesthetic isoflurane on a cyclodextrin based stationary phase using a gas chromatography simulated moving bed process is reported. Experiments have been performed to investigate the effect of major operating parameters such as switch time, flow rates, and temperature. The study demonstrated that it is possible to separate the enantiomers to a high level of purity for use in clinical trials. It has also been found that the separation is very sensitive to disturbances as compared to the enflurane system that was studied previously.