HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
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DOI：
10.1111/j.1528-1167.2010.02766.x
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发表时间：
2010-12-01
期刊：
影响因子：
5.6
通讯作者：
Hasegawa, Ryuichi
中科院分区：
文献类型：
--
作者：
Kaniwa, Nahoko;Saito, Yoshiro;Hasegawa, Ryuichi
P>；Stevens-Johnson综合征(SJS)和中毒性表皮坏死松解症(TEN)是罕见的但危及生命的严重皮肤不良反应。最近，在中国汉族患者中发现了与卡马西平诱导的SJS/TEN密切相关的HLA-B*1502。这些关联已经在除日本人以外的几个亚洲人群中得到证实。在印度和泰国的研究中发现了携带人类白细胞抗原-B*1508、人类白细胞抗原-B*1511或人类白细胞抗原-B*1521的SJS患者，它们与人类白细胞抗原-B*1502一起属于人类白细胞抗原-B75型。在本研究中，我们对14例日本典型和非典型SJS/TEN患者的人类白细胞抗原-B基因座进行了基因分型，其中卡马西平被认为与不良反应的发生有关。虽然没有发现人类白细胞抗原B*1502携带者，但有4例患者有人类白细胞抗原B*1511携带者。我们的数据提示，人类白细胞抗原-B*1511是卡马西平诱发日本人SJS/TEN的危险因素。
P>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine-induced SJS/TEN in Japanese.