Migration of Hematogenous Cells Through the Blood-Brain Barrier and the Initiation of CNS Inflammation
Migration of Hematogenous Cells Through the Blood-Brain Barrier and the Initiation of CNS Inflammation
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DOI：
10.1111/j.1750-3639.1991.tb00646.x
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发表时间：
1991-01-01
期刊：
影响因子：
6.4
通讯作者：
Hickey, William F.
中科院分区：
文献类型：
--
作者：
Hickey, William F.
中枢神经系统长期以来被认为是免疫特权部位。然而，在许多情况下，来自骨髓的细胞可以并且确实进入CNS。单核细胞/巨噬细胞谱系的衍生物似乎作为正常个体发育和生理学的一部分进入并驻留在CNS的各种结构中。免疫活性细胞，如CD 4和CD 8阳性组的T淋巴细胞，当它们被抗原刺激激活时，以似乎是随机的方式进入神经系统。这些淋巴细胞对CNS进行所需的免疫监视，并在感染和自身免疫反应期间引发其中的炎症。在这篇综述中，支持上述观察结果的证据进行了检查，并提出了中枢神经系统炎症反应的发病机制的假设。
The central nervous system has long been considered an immunologically privileged site. Nevertheless, cells derived from the bone marrow can and do enter the CNS in a number of circumstances. Derivatives of the monocyte/macrophage lineage appear to enter and take up residence in various structures of the CNS as part of normal ontogeny and physiology. Immunocompetent cells, such as T-lymphocytes of both CD4 and CD8 positive groups, enter the nervous system in what appears to be a random fashion when they are activated by antigenic stimulation. These lymphocytes perform the required immunological surveillance of the CNS, and initiate inflammation therein during infectious and autoimmune reactions. In this review, the evidence supporting the above observations is examined, and a hypothesis for the pathogenesis of CNS inflammatory reactions is presented.