Therapeutic potential of chemokine signal inhibition for metastatic breast cancer.
Therapeutic potential of chemokine signal inhibition for metastatic breast cancer.
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趋化因子信号抑制转移性乳腺癌的治疗潜力。
DOI：
10.1016/j.phrs.2015.08.004
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发表时间：
2015-10
影响因子：
9.3
通讯作者：
Pollard JW
中科院分区：
文献类型：
--
作者：
Kitamura T;Pollard JW
据报道，肿瘤浸润免疫细胞如转移相关巨噬细胞（MAM）、调节性T（Tregreg）细胞和髓源性抑制细胞（MDSC）促进致死性转移灶的建立，并限制细胞毒性药物的功效或自然杀伤（NK）和CD 8 + T细胞的杀肿瘤免疫应答。最近的研究表明，这些促肿瘤免疫细胞是在肿瘤微环境中建立的趋化因子网络中积累的。因此，阻断这些趋化因子信号可以提高化疗和免疫治疗的疗效。转移性乳腺癌是无法治愈的目前的治疗，包括化疗和免疫治疗。越来越多的证据表明，肿瘤浸润性巨噬细胞促进了致死性转移灶的建立，并有助于治疗耐药性。最近的研究表明，这些巨噬细胞的积累是由肿瘤微环境中建立的趋化因子网络调节的。在这篇前瞻性论文中，我们详细阐述了趋化因子信号，可以吸引单核细胞/巨噬细胞转移的网站，并讨论这些趋化因子信号的抑制是否可以代表转移性乳腺癌的一种新的治疗策略。
Tumor-infiltrang immune cells such as metastasis-associated macrophages (MAM), regulatory T (Tregreg) cells, and myeloid-derived suppressor cells (MDSC) are reported to promote establishment of the lethal metasta-c foci and restrict efficacy of cytotoxic drugs or tumoricidal immune responses by natural killer (NK) and CD8+ T cells. Recent studies suggest that these pro-tumor immune cells are accumulated a chemokine network established in the tumor microenvironment. Therefore, blockade of these chemokine signals could improve therapeu-c efficacy of chemotherapy and immunotherapy. Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.