Arterial spin label imaging of acute ischemic stroke and transient ischemic attack.
Arterial spin label imaging of acute ischemic stroke and transient ischemic attack.
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DOI：
10.1016/j.nic.2011.01.003
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发表时间：
2011-05
影响因子：
2.3
通讯作者：
Zaharchuk G
中科院分区：
文献类型：
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作者：
Zaharchuk G
由于急性缺血性卒中和短暂性脑缺血发作（TIA）是脑血流动力学的根本性破坏，脑灌注的神经影像学可能具有临床实用性。最近，一种非造影剂的方法来测量CBF使用动脉自旋标记（ASL）已成为可行的临床设置。与动态磁敏感对比（DSC）团注造影灌注加权成像（PWI）相比，其具有优势，包括不暴露于钆基造影剂、改善定量以及降低对磁敏感伪影和运动的敏感性。ASL的缺点包括降低的信噪比（SNR）和对动脉传输延迟的高敏感性。虽然对定量灌注测量有害，但ASL对晚到血液的敏感性可能有利于可视化侧支血流。本章将讨论急性缺血性卒中和TIA患者的ASL成像结果，重点关注典型表现、常见伪影以及与团注对比PWI的比较。
Since acute ischemic stroke and transient ischemic attack (TIA) are fundamentally disruptions of brain hemodynamics, neuroimaging of brain perfusion might be expected to be of clinical utility. Recently, a noncontrast method of measuring CBF using arterial spin labeling (ASL) has become feasible in the clinical setting. It has advantages when compared to dynamic susceptibility contrast (DSC) bolus contrast perfusion-weighted imaging (PWI) that include lack of exposure to gadolinium-based contrast materials, improved quantitation, and decreased sensitivity to susceptibility artifacts and motion. Drawbacks of ASL include reduced signal-to-noise (SNR) and high sensitivity to arterial transit delays. While deleterious for quantitative perfusion measurements, the sensitivity of ASL to late arriving blood can be beneficial to visualize collateral flow. This chapter will discuss ASL imaging findings in patients presenting with acute ischemic stroke and TIA, focusing on typical appearances, common artifacts, and comparisons with bolus contrast PWI.