SALSOLINOL AND DOPAMINE IN RAT MEDIAL BASAL HYPOTHALAMUS AFTER CHRONIC ETHANOL EXPOSURE
SALSOLINOL AND DOPAMINE IN RAT MEDIAL BASAL HYPOTHALAMUS AFTER CHRONIC ETHANOL EXPOSURE
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DOI：
10.1016/0024-3205(85)90115-8
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发表时间：
1985-01-01
期刊：
影响因子：
6.1
通讯作者：
DUNCAN, MW
中科院分区：
文献类型：
--
作者：
MYERS, WD;MACKENZIE, L;DUNCAN, MW
通过气相色谱/质谱 (GC/MS) 选择离子监测技术，使用氘代内标，测量长期暴露于乙醇 10 个月的 Long Evans 大鼠体内的猪油醇和多巴胺的内源水平。长期接触乙醇会导致下丘脑内侧基底层中的多巴胺和猪油醇浓度显着增加，但纹状体中不会增加。显然，大鼠脑组织中出现的猪油酚是体内 Pictet-Spengler 环化的结果。
Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS)-selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for 10 mo. Chronic ethanol exposure produced significant increases of dopamine and salsolinol concentrations in the medial basal hypothalamus but not striatum. Apparently the occurrence of salsolinol in rat brain tissue is a consequence of an in vivo Pictet-Spengler cyclization.