Evaluation of the Significance of Lymphatic, Microvascular and Perineural Invasion in Patients With Pancreatic Neuroendocrine Neoplasms.
Evaluation of the Significance of Lymphatic, Microvascular and Perineural Invasion in Patients With Pancreatic Neuroendocrine Neoplasms.
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DOI：
10.21873/cdp.10089
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发表时间：
2022-03-01
期刊：
影响因子：
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通讯作者：
Yamamoto, Masakazu
中科院分区：
文献类型：
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作者：
Izumo, Wataru;Higuchi, Ryota;Yamamoto, Masakazu
背景：胰腺神经内分泌肿瘤(PanNENs)的预后因素已有报道，但淋巴、微血管和神经周围侵袭的意义尚不清楚。我们旨在阐明这些因素在Pannen复发中的作用。患者和方法：我们分析了138例接受根治性胰腺切除术并经病理诊断为Pannen的患者。结果：淋巴管侵犯34例(25%)，微血管侵犯43例(31%)，神经周围侵犯17例(12%)。复发24例(17%)，3年、5年和10年无复发生存率分别为88%、84%和76%。复发部位(有重复)主要是肝脏(22例)，其次是淋巴结(7例)和骨(2例)。在多因素分析中，2-3级和微血管侵犯是RFS的显著危险因素(危险比分别为7.5和7.9)。根据这些因素检查预后时，风险评分为0、1和2的患者的5年RFS率分别为100%、91%和32%(P
Background: Some prognostic factors for pancreatic neuroendocrine neoplasms (PanNENs) have been reported; however, the significance of lymphatic, microvascular, and perineural invasion remains unclear. We aimed to clarify the role of these factors in PanNEN recurrence.Patients and Methods: We analyzed 138 patients who underwent curative pancreatectomy and were pathologically diagnosed with PanNEN. We evaluated the association between clinicopathological factors and the recurrence of PanNENs.Results: The numbers of patients with lymphatic, microvascular, and perineural invasion were 34 (25%), 43 (31%) and 17 (12%), respectively. Twenty-four patients (17%) had recurrences, and the 3, 5, and 10-year recurrence-free survival (RFS) rates were 88%, 84%, and 76%, respectively. The recurrence sites (with duplication) were mainly the liver (twenty-two patients), followed by the lymph nodes (seven patients), and bone (two patients). In multivariate analyses, grade 2-3 and the presence of microvascular invasion were significant risk factors for RFS (hazard ratio=7.5 and 7.9, respectively). When examining outcomes according to these factors, the 5-year RFS rates of patients with risk scores of 0, 1, and 2 were 100%, 91%, and 32%, respectively (p