CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients.
CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients.
复制标题
CD4 淋巴细胞减少症是肾移植受者皮肤癌的危险因素。
作者：
D. Ducloux;Pierre;J. Rebibou;Fran??ois Aubin;V??ronique Fournier;C. Bresson‐Vautrin;Dominique Blanc;Philippe Humbert;J. Chalopin
背景
肾移植受者患皮肤癌的风险增加。目前仍难以确定过度免疫抑制对皮肤癌发展的实际影响。我们研究了淋巴细胞亚群计数是否可以预测长期肾移植受者发生皮肤癌的风险。
方法
对150例长期肾移植受者进行了平均26个月的随访。每位患者至少每年由皮肤科医生检查一次。每年测量淋巴细胞亚群。
结果
15名患者出现皮肤癌。皮肤癌患者和非皮肤癌患者在年龄、性别、移植持续时间、移植前血液透析持续时间、免疫抑制方案和血清肌酐浓度方面没有差异。皮肤癌患者的CD 4细胞计数显著较低（330+/-179/mm3 vs. 503+/-338/mm3; P<0.01），而两组之间的总淋巴细胞和CD 8和CD 19细胞计数相似。
结论
CD 4细胞耗竭与长期肾移植受者的皮肤癌相关
BACKGROUND
Renal transplant recipients are at increased risk of developing skin cancer. It remains difficult to establish the actual influence of overimmunosuppression in the development of skin cancers. We investigated whether lymphocyte subset count may predict the risk of developing skin cancer in long-term renal transplant recipients.
METHODS
One hundred fifty long-term renal transplant recipients were followed for a mean period of 26 months. Each patient was examined at least annually by a dermatologist. Lymphocyte subsets were measured annually.
RESULTS
Fifteen patients exhibited skin cancers. Patients with and without skin cancer did not differ in age, gender, transplant duration, hemodialysis duration before transplantation, immunosuppressive regimen, and serum creatinine concentration. CD4 cell counts were significantly lower in patients with skin cancers (330+/-179/mm3 vs. 503+/-338/mm3; P<0.01), whereas total lymphocyte and CD8 and CD19 cell counts were similar between the two groups.
CONCLUSIONS
CD4 cell depletion is associated with skin cancer in long-term renal transplant recipients.
环孢素治疗和非环孢素治疗的成人原发性同种异体肾移植受者中的新生癌症。
影响因子：
2.1
作者：
Gruber,SA;Gillingham,K;Sothern,RB;Stephanian,E;Matas,AJ;Dunn,DL
通讯作者：
Dunn,DL
获得性免疫缺陷综合征患者的播散性疣和进展的鳞状细胞癌。
影响因子：
13.8
作者：
Milburn,PB;Brandsma,JL;Goldsman,CI;Teplitz,ED;Heilman,EI
通讯作者：
Heilman,EI
各种人类感染期间淋巴细胞表面标记物的变化。
DOI：
10.1016/0002-9343(83)90412-6
发表时间：
1983
期刊：
The American journal of medicine
影响因子：
--
作者：
WilliamsJr,RC;Koster,FT;Kilpatrick,KA
通讯作者：
Kilpatrick,KA