Macrophage activation: increased ingestion of IgG-coated erythrocytes after administration of interferon inducers to mice.
Macrophage activation: increased ingestion of IgG-coated erythrocytes after administration of interferon inducers to mice.
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DOI：
10.1084/jem.147.2.593
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发表时间：
1978-02-01
影响因子：
15.3
通讯作者：
Rabinovitch, M
中科院分区：
文献类型：
--
作者：
Hamburg, S I;Manejias, R E;Rabinovitch, M
IgG调理的绵羊红细胞（EA）的体外吞噬作用用于测量小鼠腹腔巨噬细胞的体内活化。通过腹膜外给予纽卡斯尔病病毒、水泡性口炎病毒、替洛酮或聚肌胞苷酸，增强EA的摄取。EA的摄入同样受到脂多糖或杀死的短棒状杆菌的刺激。处理组和对照组动物的IgG浓度与吞噬作用相关的剂量-反应曲线平行。这表明巨噬细胞群体的异质性没有改变，并且总体群体在吞噬能力方面被激活。巨噬细胞数量无明显增加（C. parvum处理的小鼠），表明驻留的而不是新募集的巨噬细胞被不同的试剂激活。
In vitro phagocytosis of IgG-opsonized sheep erythrocytes (EA) was used to measure the in vivo activation of mouse peritoneal macrophages. Uptake of EA as enhanced by the extraperitoneal administration of Newcastle disease virus, vesicular stomatitis virus, tilorone or polyinosinic-polycytidylic acid. Ingestion of EA was similarly stimulated by lipopolysaccharide or killed Corynebacterium parvum. Dose- response curves relating concentrations of IgG to phagocytosis were parallel for both treated and control animals. This indicates that the heterogeneity of the macrophage populations did not change and that the overall populations were activated with respect to phagocytic ability. Numbers of macrophages were not increased (except in C. parvum-treated mice), suggesting that resident, rather than newly recruited macrophages, were activated by the different agents.