Heritability of adult body height:: A comparative study of twin cohorts in eight countries
Heritability of adult body height:: A comparative study of twin cohorts in eight countries
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DOI：
10.1375/136905203770326402
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发表时间：
2003-10-01
期刊：
影响因子：
--
通讯作者：
Kaprio, J
中科院分区：
文献类型：
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作者：
Silventoinen, K;Sammalisto, S;Kaprio, J
身高差异的一个主要因素是遗传差异，但环境因素也有很大的影响。在这项研究中，我们旨在分析在富裕的西方社会中身高的遗传结构是否存在差异。我们使用Mx统计包的单变量遗传模型分析了来自8个国家的双胞胎数据，包括30,111对完整的双胞胎。身高和合合度在7个人群中自我报告，并在一个人群中直接测量。我们发现，不同国家的平均身高有很大差异；意大利人的身高最低（男性177厘米，女性163厘米），荷兰人的身高最高（分别为184厘米和171厘米）。在男性中，身高的遗传率没有相应的变化，在加性基因/独特环境（AE）模型下，遗传率估计在0.87至0.93之间。女性的遗传力估计值普遍低于男性，不同国家之间的差异更大，当使用加性基因/共享环境/独特环境（ACE）模型时，遗传力估计值从0.68到0.84不等。在AE模型拟合同样好或更好的四个种群中，遗传率从0.89到0.93不等。两性之间的差异主要是由于共同的环境因素的影响，在我们的研究人群中，这在女性中似乎比在男性中更重要。我们的研究结果表明，总的来说，富裕的高加索人群，尤其是男性，在身高的遗传结构上只有很小的差异。
A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were self-reported in seven populations and measured directly in one population. We found that there was substantial variation in mean body height between countries; body height was least in Italy (177 cm in men and 163 cm in women) and greatest in the Netherlands (184 cm and 171 cm, respectively). In men there was no corresponding variation in heritability of body height, heritability estimates ranging from 0.87 to 0.93 in populations under an additive genes/unique environment (AE) model. Among women the heritability estimates were generally lower than among men with greater variation between countries, ranging from 0.68 to 0.84 when an additive genes/shared environment/unique environment (ACE) model was used. In four populations where an AE model fit equally well or better, heritability ranged from 0.89 to 0.93. This difference between the sexes was mainly due to the effect of the shared environmental component of variance, which appears to be more important among women than among men in our study populations. Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men.