Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity
Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity
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DOI：
10.1016/j.oraloncology.2006.10.009
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发表时间：
2007-09-01
期刊：
影响因子：
4.8
通讯作者：
Whiteside, Theresa L.
中科院分区：
文献类型：
--
作者：
Kunkel, Martin;Moergel, Maximilian;Whiteside, Theresa L.
本研究验证了GLUT-1是口腔鳞状细胞癌（OSCC）放射抗性标志物的假设。采用免疫组化法检测40例口腔鳞癌活检标本中GLUT-1的标记指数（LI）。根据切除标本的组织病理学对辐射反应进行分类。对LI与放疗反应、Kaplan-Meier生存率估计值以及GLUT-1、T分期、N分期和化疗变量的考克斯回归分析进行了研究。中位LI为64.2%（范围14-100%）。具有>65%的GLUT-1 +细胞的肿瘤对辐射的抗性更强（p = 0.023）。低LI（中位数）受试者的总生存期较高（p = 0.044）。考克斯回归分析证实了GLUT-1的预后意义。我们的研究结果表明，治疗前GLUT-1在肿瘤中的表达是口腔鳞癌放射抵抗的标志，高表达与放射反应差和生存期短有关。(C)2006爱思唯尔有限公司版权所有。
This study tested the hypothesis that GLUT-1 is a marker of radioresistance in oral squamous cell carcinomas (OSCC). A GLUT-1 labeling index (LI) was determined by immunohistochemistry in 40 pretreatment OSCC biopsies. Radiation responses were categorized by histopathology of the resection specimens. Associations between the LI and radiation response, Kaplan-Meier survival estimates and Cox regression analysis for the variables GLUT-1, T-stage, N-stage and chemotherapy were examined. The median LI was 64.2% (range 14-100%). Tumors with >65% of GLUT-1 + cells were more resistant to radiation (p = 0.023). Overall survival was higher (p = 0.044) for subjects with low LI (median value). The Cox regression analysis confirmed the prognostic significance of GLUT-1. Our results indicate that pre-treatment GLUT-1 expression in the tumor is a marker of radioresistance in OSCC, with high expression being associated with poor radiation response and shorter survival. (C) 2006 Elsevier Ltd. All rights reserved.