Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.
Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.
复制标题
辛酸可抑制特发性震颤小鼠模型中骆驼蓬碱引起的震颤。
DOI：
10.1007/s13311-012-0121-1
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hallett,Mark
中科院分区：
文献类型：
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作者：
Nahab,FattaB;Handforth,Adrian;Brown,Tyler;Shin,Christopher;Quesada,Arnulfo;Dong,Chuanhui;Haubenberger,Dietrich;Hallett,Mark
最近的工作探索使用高分子量醇治疗特发性震颤（ET）已确定辛酸作为一种潜在的新型震颤抑制剂。我们使用了一个建立的骆驼蓬碱为基础的小鼠模型ET比较震颤抑制1-辛醇和辛酸。分析了对震颤带宽内的数字化运动功率的剂量相关效应（作为总体运动功率的一部分）。1-辛醇和辛酸均显著降低了震颤性震颤。8-碳烷基醇和羧酸各自抑制ET的临床前小鼠模型中的震颤。进一步的研究是必要的，以确定这些药物在人类与ET的安全性和有效性。
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.