Albumin in the cornea is oxidized by hydrogen peroxide.
Albumin in the cornea is oxidized by hydrogen peroxide.
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角膜中的白蛋白被过氧化氢氧化。
DOI：
10.1097/00003226-199211000-00014
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发表时间：
1992
期刊：
影响因子：
2.8
通讯作者：
Crouch,RK
中科院分区：
文献类型：
--
作者：
Zhu,L;Crouch,RK
本文研究了过氧化氢对大鼠角膜可溶性蛋白质的作用。发现两种主要的角膜蛋白质被10 mM的过氧化氢氧化。蛋白质序列和抗体识别表明，其中一种蛋白质是白蛋白。用过氧化氢处理纯大鼠或人血清白蛋白会使蛋白质氧化，并降低其与抗体的亲和力。因为白蛋白是角膜中的主要蛋白质，它的氧化作用表明白蛋白在这个组织中的作用可能是作为一种天然的抗氧化剂，清除过氧化氢，从而防止这种毒素造成更广泛的损害。这些数据与评估含过氧化氢的隐形眼镜消毒剂的安全性有关，并表明有必要进一步研究这种氧化剂的作用。
The action of hydrogen peroxide on soluble proteins of the rat cornea has been evaluated. Two major corneal proteins are found to be oxidized by 10 mM hydrogen peroxide. Protein sequence and antibody recognition has shown one of the proteins to be albumin. Treatment of pure rat or human albumin with hydrogen peroxide oxidizes the protein and decreases its affinity for its antibody. Because albumin is a major protein in the cornea, its ready oxidation suggests that a role for albumin in this tissue may be to act as a native antioxidant, scavenging hydrogen peroxide and thus preventing more extensive damage by this toxin. These data are relevant to the evaluation of the safety of contact lens disinfectants containing hydrogen peroxide and suggest that further study of the action of this oxidant is warranted