Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
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萼短茎根中的糖尿病肾病相关活性环肽
DOI：
10.1016/j.bmcl.2011.10.004
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发表时间：
2011-12-15
影响因子：
2.7
通讯作者：
Hou, Fan-Fan
中科院分区：
文献类型：
--
作者：
Cheng, Yong-Xian;Zhou, Li-Li;Hou, Fan-Fan
从治疗风湿病的传统药物Brachystemma calycinum 的根中分离出三种新的环肽，即duanbanhuains A-C (1-3)。通过一系列 MS 和 NMR 实验鉴定了它们的结构。我们特意评估了这些化合物对高血糖刺激的肾小球系膜细胞的 MCP-1、IL-6、IV 型胶原蛋白和活性氧 (ROS) 释放的抑制作用。结果表明，化合物1和2在10μM浓度下对IL-6、胶原IV和ROS的产生具有有效的抑制作用。(C)2011 Elsevier Ltd.版权所有。
Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.