Autonomic responses during inhalation of natural fragrance of "Cedrol" in humans
Autonomic responses during inhalation of natural fragrance of "Cedrol" in humans
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DOI：
10.1016/j.autneu.2003.08.002
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发表时间：
2003-10-31
影响因子：
2.7
通讯作者：
Nishijo, H
中科院分区：
文献类型：
--
作者：
Dayawansa, S;Umeno, K;Nishijo, H
众所周知，气味影响行为和自主神经功能。以前的研究报道了雪松香精中的一些化合物引起行为改变，包括镇静作用。在本研究中，我们分析了受试者在吸入从雪松木油中提取的纯化合物（雪松醇）烟雾时的心血管和呼吸功能。将汽化的柏油（14.2 +/- 1.7杯/升，5升/分钟）和空白空气（5升/分钟）通过面罩给健康受试者（n = 26），同时监测心电图、心率（HR）、收缩压（SBP）、舒张压（DBP）和呼吸频率（RR）。统计分析表明，与空白空气相比，暴露于雪松醇可显著降低心率、收缩压和舒张压，同时增加压力感受器敏感性。此外，在暴露于雪松醇期间，呼吸速率降低。这些结果，以及先前报道呼吸和心血管功能之间密切关系的研究表明，这些呼吸功能的变化与上述心血管改变是一致的。频谱分析显示，吸入雪松醇时，高频成分（副交感神经活动指数）增加，低频与高频成分（LF/HF）之比（交感迷走神经平衡指数）降低。此外，雪松醇吸入显著降低收缩压和舒张压变异性的LF成分，这反映了血管舒缩性交感神经活动。综上所述，这些自主神经参数的变化模式表明，香柏木吸入引起副交感神经活动的增加和交感神经活动的减少，这与香柏木有松弛作用的观点一致。(C) 2003 Elsevier B.V.版权所有
It is well known that odors affect behaviors and autonomic functions. Previous studies reported that some compounds in cedar wood essence induced behavioral changes including sedative effects. In the present study, we analyzed cardiovascular and respiratory functions while subjects were inhaling fumes of pure compound (Cedrol) which was extracted from cedar wood oil.Vaporized Cedrol (14.2 +/- 1.7 mug/l, 5 l/min) and blank air (5 l/min) were presented to healthy human subjects (n = 26) via a face mask, while ECGs, heart rate (HR), systolic blood pressure (SBP), diastolic BP (DBP), and respiratory rates (RR) were monitored. Statistical analyses indicated that exposure to Cedrol significantly decreased HR, SBP, and DBP compared to blank air while it increased baroreceptor sensitivity. Furthermore, respiratory rate was reduced during exposure to Cedrol. These results, along with the previous studies reporting close relationship between respiratory and cardiovascular functions, suggest that these changes in respiratory functions were consistent with above cardiovascular alterations.Spectral analysis of RR variability indicated an increase in high frequency (HF) component (index of parasympathetic activity), and a decrease in ratio of low frequency to high frequency components (LF/HF) (index of sympathovagal balance) during Cedrol inhalation. Furthermore, Cedrol inhalation significantly decreased LF components of both SBP and DBP variability, which reflected vasomotor sympathetic activity. Taken together, these patterns of changes in the autonomic parameters indicated that Cedrol inhalation induced an increase in parasympathetic activity and a reduction in sympathetic activity, consistent with the idea of a relaxant effect of Cedrol. (C) 2003 Elsevier B.V. All rights reserved.