The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children
The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children
复制标题
脂肪细胞因子vaspin和visfatin在肥胖儿童血管内皮功能和胰岛素抵抗中的作用
DOI：
10.1186/s12902-019-0452-6
复制
发表时间：
2019-11-26
影响因子：
2.7
通讯作者：
Xiao, Yanfeng
中科院分区：
文献类型：
--
作者：
Yin, Chunyan;Hu, Wei;Xiao, Yanfeng
研究背景：我们检测了中国肥胖儿童脂肪细胞因子vaspin和visfatin的浓度。此外，我们研究了这些脂肪细胞因子与这些儿童中早发性代谢和血管后遗症的相关性。方法244例儿童（肥胖160例，偏瘦84例）纳入研究。采用酶联免疫吸附试验检测Vaspin和visfatin。我们还检测了其他代谢和心血管参数。测定血清vaspin和visfatin浓度与代谢和心血管参数的关系。结果我们发现肥胖儿童的vaspin和visfatin浓度显著高于消瘦儿童。此外，我们发现内脂素和vaspin水平，以及炎症细胞浸润和内皮活化标志物之间存在显著的正相关性，但这些因素并不影响肥胖儿童的胰岛素抵抗。多元回归分析证实，vaspin是肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血管紧张素-2（Ang-2）、血管细胞粘附分子-1（VCAM-1）和E-选择素水平升高的最强预测因子。我们还发现内脂素与Ang-2、IL-6、VCAM-1和E-选择素水平之间存在显着相关性。结论脂肪细胞因子vaspin和visfatin具有明显的相关性，二者均参与血管内皮功能和炎症反应。
Background We measured the concentrations of the adipocytokines vaspin and visfatin in obese Chinese children. Furthermore, we studied the correlation of these adipocytokines with early-onset metabolic and vascular sequelae among these children. Methods A total of 244 children (160 obese and 84 lean) were included in this study. Vaspin and visfatin were detected using enzyme-linked immunosorbent assays. We also assayed other metabolic and cardiovascular parameters. The associations of serum vaspin and visfatin concentrations with metabolic and cardiovascular parameters were determined. Results We found a significant elevation in the concentrations of vaspin and visfatin in obese children compared to the concentrations in lean children. Additionally, we found a significant positive correlation between visfatin and vaspin levels, as well as inflammatory cell infiltration and markers of endothelial activation, but these factors did not affect insulin resistance in obese children. Multiple regression analyses confirmed that vaspin is the strongest predictor of higher tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), angiotensin-2 (Ang-2), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin levels. We also found a significant association between visfatin and Ang-2, IL-6, VCAM-1, and E-selectin levels. Conclusion The adipocytokines vaspin and visfatin are significantly interrelated, and both adipocytokines play a role in vascular endothelial function and inflammation.