Relationship between Modulator Recognition Factor 2/AT-rich Interaction Domain 5B Gene Variations and Type 2 Diabetes Mellitus or Lipid Metabolism in a Northern Chinese Population.
Relationship between Modulator Recognition Factor 2/AT-rich Interaction Domain 5B Gene Variations and Type 2 Diabetes Mellitus or Lipid Metabolism in a Northern Chinese Population.
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中国北方人群调节器识别因子 2/富含 AT 的相互作用域 5B 基因变异与 2 型糖尿病或脂质代谢的关系
DOI：
10.4103/0366-6999.204926
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发表时间：
2017-05-05
影响因子：
6.1
通讯作者：
Qiao H
中科院分区：
文献类型：
--
作者：
Sun LL;Zhang SJ;Chen MJ;Elena K;Qiao H
背景资料：位于染色体10q21.2的调节识别因子2/AT富集相互作用域5 B（MRF 2/ARID 5 B）基因中的4个单核苷酸多态性（SNP）已被证明与日本队列中的2型糖尿病（T2 DM）和冠状动脉疾病相关。本研究旨在探讨这些SNPs（rs 2893880、rs 10740055、rs7087507、rs 10761600）与中国北方人群新发2型糖尿病及脂代谢的关系。方法：采用病例对照研究。通过SNP扫描对rs 2893880、rs 10740055、rs7087507和rs 10761600基因变异进行基因分型，并分析其与2000例T2 DM易感性的关系（999例新诊断的T2 DM患者和1001例非糖尿病对照者）。多因素Logistic回归分析MRF 2/ARID 5 B基因型与2型糖尿病的相关性。结果如下：关于rs 10740055 SNP，与共显性CC型相比，AA与T2 DM的风险更高相关（经性别、年龄和体重指数[BMI]调整，P = 0.041，比值比[OR] = 1.421，95%置信区间[CI] 1.014-1.991）。同时，AA个体与CC或单一C个体相比，呈现T2 DM的风险增加（经性别、年龄和BMI调整，P = 0.034，OR = 1.366，95%CI 1.023-1.824）。关于rs 10761600，与AA相比，AT导致T2 DM的风险更高（经性别、年龄和BMI调整，P = 0.013，OR = 1.585，95%CI 1.101-2.282），而TT也增加了与AA或A相比出现T2 DM的风险经性别、年龄和BMI调整后，P = 0.004，OR = 1.632，95%CI 1.166-2.284）。对照组中rs7087507基因型间高密度脂蛋白胆固醇（HDL-C）水平差异有统计学意义（P = 0.048）（GG>GA）。结论：目前的结果确定MRF 2/ARID 5 B是中国北方人群新发T2 DM的潜在易感基因，而rs 7087507 SNP与HDL-C水平相关。需要进一步的更大规模的研究来验证这些发现。
Background: Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort. This study aimed to investigate the relationship between these SNPs (rs2893880, rs10740055, rs7087507, rs10761600) and new-onset T2DM and lipid metabolism in a Northern Chinese population. Methods: This was a case-control study. The rs2893880, rs10740055, rs7087507, and rs10761600 genetic variants were genotyped by SNPscan and analyzed in relation to T2DM susceptibility in 2000 individuals (999 with newly diagnosed T2DM and 1001 controls without diabetes mellitus). Associations between the MRF2/ARID5B genetic models and T2DM were determined by multivariate logistic regression. Results: Regarding the rs10740055 SNP, AA was associated with a higher risk of T2DM compared with codominant-type CC (adjusted by sex, age, and body mass index [BMI], P = 0.041, odds ratio [OR] = 1.421, 95% confidence interval [CI] 1.014–1.991). Meanwhile, AA individuals were at increased risk of presenting with T2DM compared with individuals with CC or a single C (adjusted by sex, age, and BMI, P = 0.034, OR = 1.366, 95% CI 1.023–1.824). With respect to rs10761600, AT contributed to a higher risk of T2DM compared with AA (adjusted by sex, age, and BMI, P = 0.013, OR = 1.585, 95% CI 1.101–2.282), while TT also increased the risk of presenting with T2DM compared with AA or A (adjusted by sex, age, and BMI, P = 0.004, OR = 1.632, 95% CI 1.166–2.284). High-density lipoprotein cholesterol (HDL-C) levels were significantly different among the three genotypes of rs7087507 in the controls (P = 0.048) (GG>GA). Conclusions: The present results identified MRF2/ARID5B as a potential susceptibility gene for new-onset T2DM in a Northern Chinese population, while the rs7087507 SNP was associated with HDL-C levels. Further larger studies are required to validate these findings.