Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration
Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration
复制标题
DOI：
10.1016/s0264-410x(99)00572-1
复制
发表时间：
2000-05-08
期刊：
影响因子：
5.5
通讯作者：
Ulrich, JT
中科院分区：
文献类型：
--
作者：
Baldridge, JR;Yorgensen, Y;Ulrich, JT
由粘膜途径递送的疫苗诱导保护性免疫依赖于安全有效的粘膜佐剂的开发。免疫刺激物单磷酰脂质A （MPL(R)）被评价其增强对三种不同抗原的全身和粘膜免疫的能力。用MP(R)和乙型肝炎表面抗原配制的疫苗。破伤风环形或流感抗原经鼻内给药给小鼠。在每种情况下，用MPL(R)配制的疫苗都能提高粘膜样品的IgA滴度。在局部和远端粘膜部位的样本中检测到IgA浓度增强。此外，MPL(R)配制的疫苗诱导了具有thl型应答特征的全身免疫。血清IgG2a抗体滴度升高，细胞毒性T细胞活性增强。(C) 2000 Elsevier Science Ltd.版权所有。
The induction of protective immunity stemming from vaccines delivered by mucosal routes is dependent on the development of safe and effective mucosal adjuvants. The immunostimulant monophosphoryl lipid A (MPL(R)) was evaluated for its ability to enhance both systemic and mucosal immunity to three distinct antigens. Vaccines formulated with MP(R) and hepatitis B surface antigen. tetanus toroid or influenza antigens were administered by intranasal delivery to mice. In each case the vaccines formulated with MPL(R) resulted in enhanced IgA titers from mucosal samples. Enhanced IgA concentrations were detected in samples from both local and distal mucosal sites. In addition, the MPL(R) formulated vaccines induced systemic immunity characteristic of a Thl-type of response. Serum IgG2a antibody titers were elevated and cytotoxic T cell activity was enhanced. (C) 2000 Elsevier Science Ltd. All rights reserved.