Effects of ethanol during the onset of female puberty.
Effects of ethanol during the onset of female puberty.
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DOI：
10.1159/000125317
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发表时间：
1990
影响因子：
4.1
通讯作者：
Les Dees;C. Skelley
中科院分区：
文献类型：
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作者：
Les Dees;C. Skelley
为了更密切地评估乙醇（ETOH）延迟雌性青春期开始的生理机制，我们评价了其对大鼠体重、阴道开口（VO）-第一次动情间期（D1）间隔以及整个青春期围期血清生长激素（GH）、促黄体生成激素（LH）和促卵泡激素（FSH）浓度的影响。使用特定的胃内喂养方案，29日龄大鼠开始接受含ETOH的流质饮食或等热量对照流质饮食。其他对照组包括动物，动物可自由进食实验室饲料和水。在32 - 37日龄之间处死动物，根据其青春期阶段进行分类，并测量其血清激素;或者，在一些动物中，给予ETOH流质饲料至第41天，并在此时用对照流质饲料替代，以确定是否会恢复。我们的结果表明，ETOH处理的动物显示出比对照动物显著更低的体重和显著更长的平均VO-D1间期。此外，ETOH给药动物的血清GH和LH水平显著降低;然而，FSH水平不受影响。直至第41天给予ETOH液体饲料对青春期的开始产生不同的有害影响，随后从饲料中去除ETOH导致动物快速生长，随后青春期开始。（250字处删节）
To assess more closely the physiological mechanism(s) by which ethanol (ETOH) delays the onset of female puberty, we have evaluated its effects on body weight, the vaginal opening (VO)-first diestrus (D1) interval and the serum concentrations of growth hormone (GH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) throughout the peripubertal period in the rat. Using a specific intragastric feeding regimen, 29-day-old rats began receiving either a liquid diet containing ETOH or an isocaloric control liquid diet. Additional controls consisted of animals maintained on laboratory chow and water provided ad libitum. Animals were either killed between 32 and 37 days of age, categorized with regard to their phase of puberty and their serum hormones measured; or, in some animals, the ETOH liquid diet was administered through day 41 and at that time replaced by the control liquid diet in order to determine if recovery would occur. Our results indicate that ETOH-treated animals showed significantly lower body weights and a significantly longer mean VO-D1 interval than the control animals. Also, serum GH and LH levels were significantly lower in the ETOH-treated animals; however, FSH levels were not affected. Administration of the ETOH liquid diet through day 41 produced varying detrimental effects on the onset of puberty and subsequent removal of ETOH from the diet resulted in rapid growth of the animals, followed by the onset of puberty.(ABSTRACT TRUNCATED AT 250 WORDS)