Risk factors for esophageal cancer:a case-control study in Anxi county
Risk factors for esophageal cancer:a case-control study in Anxi county
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作者：
Shi Xi-shun
目的：探讨福建省安溪县食道癌的危险因素及家族史与环境因素的交互作用。这将有助于揭示安溪县食管癌高发的原因。方法：采用标准化问卷，对185例EC患者和370例年龄、性别、居住地相匹配的对照进行1：2配对病例对照研究。采用条件Logistic回归分析食管癌的危险因素及家族史与环境因素的交互作用。结果：1食源性食管炎的危险因素有吸烟量(OR=2.681)、高盐饮食(OR=4.463)、红薯干摄入量(OR=4.891)、食管性食管炎家族史(OR=4.675)、自我约束倾向(OR=1.507)。食源性食管炎的保护因素有：食物保存在冰箱(OR=0.136)、干燥处(OR=0.093)、规律饮食(OR=0.441)、食用新鲜蔬菜(OR=0.328)、谷类食品(OR=0.583)、蒜类蔬菜(OR=0.397)。2食管炎家族史与高盐饮食(OR=5.760)、少吃葱菜(OR=7.373)、饮用过热茶(OR=8.396)之间存在协同作用。结论：安溪县食管癌的高发除与环境因素有关外，还与食管癌家族史有关。环境因素和家族史在EC的发展过程中存在一定的交互作用。
Objective:Aimed to examine the risk factors for esophageal cancer (EC) and the interactions between family history and environmental factors in etiology of EC in Anxi county of Fujian Province. This will be useful for revealing the reason for the high incidence of EC in Anxi county. Methods:Using standardized questionnaire,1∶2 matched case-control study was performed on 185 cases of EC and 370 controls for age,gender,and residence-matched. Conditional logistic regression was used to analyze the risk factors for EC and the interactions between family history and environmental factors. Results:①The risk factors of EC included tobacco smoking amount (OR=2.681), high salt diet (OR=4.463), intake of dried sweet potato (OR=4.891), the family history of EC(OR=4.675), tendency to self-restraint (OR=1.507). The protective factors of EC included conservation of food in refrigerator (OR=0.136) and dry place (OR=0.093), regular diet (OR=0.441), intake of fresh vegetables (OR=0.328),cereal (OR=0.583), and allium vegetables (OR=0.397). ②There were synergistic interactions between the family history of EC and high salt diet (OR=5.760), lack of intake of allium vegetables (OR=7.373), and consumption of over-hot tea (OR=8.396). Conclusion:The high incidence of EC in Anxi county is not only related with environmental factors but also related with family history of EC. The environmental factors and the family history have certain interactions in the development of EC.