Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Shungin, Dmitry;Winkler, Thomas W.;Croteau-Chonka, Damien C.;Ferreira, Teresa;Lockes, Adam E.;Maegi, Reedik;Strawbridge, Rona J.;Pers, Tune H.;Fischer, Krista;Justice, Anne E.;Workalemahu, Tsegaselassie;Wu, Joseph M. W.;Buchkovich, Martin L.;Heard-Costa, Nancy L.;Roman, Tamara S.;Drong, Alexander W.;Song, Ci;Gustafsson, Stefan;Day, Felix R.;Esko, Tonu;Fall, Tove;Kutalik, Zoltan;Luan, Jian'an;Randall, Joshua C.;Scherag, Andre;Vedantam, Sailaja;Wood, Andrew R.;Chen, Jin;Fehrmann, Rudolf;Karjalainen, Juha;Kahali, Bratati;Liu, Ching-Ti;Schmidt, Ellen M.;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bragg-Gresham, Jennifer L.;Buyske, Steven;Demirkan, Ayse;Ehret, Georg B.;Feitosa, Mary F.;Goel, Anuj;Jackson, Anne U.;Johnson, Toby;Kleber, Marcus E.;Kristiansson, Kati;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Palmer, Cameron D.;Pasko, Dorota;Pechlivaniss, Sonali;Peters, Marjolein J.;Prokopenko, Inga;Stancakova, Alena;Sung, Yun Ju;Tanakam, Toshiko;Teumer, Alexander;Van Vliet-Ostaptchouk, Jana V.;Yengo, Loic;Zhang, Weihua;Albrecht, Eva;Arnlov, Johan;Arscott, Gillian M.;Bandinelli, Stefania;Barrett, Amy;Bellis, Claire;Bennett, Amanda J.;Berne, Christian;Blueher, Matthias;Buhringer, Stefan;Bonnet, Fabrice;Boettcher, Yvonne;Bruinenberg, Marcel;Carba, Delia B.;Caspersen, Ida H.;Clarke, Robert;Daw, E. Warwick;Deelen, Joris;Deelman, Ewa;Delgado, Graciela;Doney, Alex S. F.;Eklund, Niina;Erdos, Michael R.;Estrada, Karol;Eury, Elodie;Friedrichs, Nele;Garcia, Melissa E.;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S.;Golay, Alain;Grallert, Harald;Grammer, Tanja B.;Graessler, Juergen;Grewal, Jagvir;Groves, Christopher J.;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A.;Hassinen, Maija;Hayward, Caroline;Heikkila, Kauko;Herzig, Karl-Heinz;Helmer, Quinta;Hillege, Hans L.;Holmen, Oddgeir;Hunt, Steven C.;Isaacs, Aaron;Ittermann, Till;James, Alan L.;Johansson, Ingegerd;Juliusdottir, Thorhildur;Kalafati, Ioanna-Panagiota;Kinnunen, Leena;Koenig, Wolfgang;Kooner, Ishminder K.;Kratzer, Wolfgang;Lamina, Claudia;Leander, Karin;Lee, Nanette R.;Lichtner, Peter;Lind, Lars;Lindstrom, Jaana;Lobbens, Stephane;Lorentzon, Mattias;Mach, Francois;Magnusson, Patrik K. E.;Mahajan, Anubha;McArdle, Wendy L.;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Mills, Rebecca;Moayyeri, Alireza;Monda, Ken L.;Mooijaart, Simon P.;Muehleisen, Thomas W.;Mulas, Antonella;Mueller, Gabriele;Mueller-Nurasyid, Martina;Nagaraja, Ramaiah;Nalls, Michael A.;Narisu, Narisu;Glorioso, Nicola;Nolte, Ilja M.;Olden, Matthias;Rayner, Nigel W.;Renstrom, Frida;Ried, Janina S.;Robertson, Neil R.;Rose, Lynda M.;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Sennblad, Bengt;Seufferlein, Thomas;Sitlani, Colleen M.;Smith, Albert Vernon;Stirrups, Kathleen;Stringham, Heather M.;Sundstrom, Johan;Swertz, Morris A.;Swift, Amy J.;Syvanen, Ann-Christine;Tayo, Bamidele O.;Thorand, Barbara;Thorleifsson, Gudmar;Tomaschitz, Andreas;Troffa, Chiara;van Oort, Floor V. A.;Verweij, Niek;Vonk, Judith M.;Waite, Lindsay L.;Wennauer, Roman;Wilsgaard, Tom;Wojczynski, Mary K.;Wong, Andrew;Zhang, Qunyuan;Zhao, Jing Hua;Brennan, Eoin P.;Choi, Murim;Eriksson, Per;Folkersen, Lasse;Franco-Cereceda, Anders;Gharavi, Ali G.;Hedman, Asa K.;Hivert, Marie-France;Huang, Jinyan;Kanoni, Stavroula;Karpe, Fredrik;Keildson, Sarah;Kiryluk, Krzysztof;Liang, Liming;Lifton, Richard P.;Ma, Baoshan;McKnight, Amy J.;McPherson, Ruth;Metspalu, Andres;Min, Josine L.;Moffatt, Miriam F.;Montgomery, Grant W.;Murabito, Joanne M.;Nicholson, George;Nyholt, Dale R.;Olsson, Christian;Perry, John R. B.;Reinmaa, Eva;Salem, Rany M.;Sandholm, Niina;Schadt, Eric E.;Scott, Robert A.;Stolk, Lisette;Vallejo, Edgar E.;Westra, Harm-Jan;Zondervan, Krina T.;Amouyel, Philippe;Arveiler, Dominique;Bakker, Stephan J. L.;Beilby, John;Bergman, Richard N.;Blangero, John;Brown, Morris J.;Burnier, Michel;Campbell, Harry;Chakravarti, Aravinda;Chiness, Peter S.;Claudi-Boehmi, Simone;Collins, Francis S.;Crawford, Dana C.;Danesh, John;de Faire, Ulf;de Geusl, Eco J. C.;Doerr, Marcus;Erbel, Raimund;Eriksson, Johan G.;Farrall, Martin;Ferrannini, Ele;Ferrieres, Jean;Forouhi, Nita G.;Forrester, Terrence;Franco, Oscar H.;Gansevoort, Ron T.;Gieger, Christian;Gudnason, Vilmundur;Haiman, Christopher A.;Harris, Tamara B.;Hattersley, Andrew T.;Heliovaara, Markku;Hicks, Andrew A.;Hingorani, Aroon D.;Hoffmann, Wolfgang;Hofman, Albert;Homuth, Georg;Humphries, Steve E.;Hyppoenen, Elina;Illig, Thomas;Jarvelin, Marjo-Riitta;Johansen, Berit;Jousilahti, Pekka;Jula, Antti M.;Kaprio, Jaakko;Kee, Frank;Keinanen-Kiukaanniemi, Sirkka M.;Kooner, Jaspal S.;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T.;Kumari, Meena;Kuulasmaa, Kari;Kuusisto, Johanna;Lakka, Timo A.;Langenberg, Claudia;Le Marchand, Loic;Lehtimaki, Terho;Lyssenko, Valeriya;Mannisto, Satu;Marette, Andre;Matise, Tara C.;McKenzie, Colin A.;McKnight, Barbara;Musk, Arthur W.;Mohlenkamp, Stefan;Morris, Andrew D.;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J.;Ong, Ken K.;Palmer, Lyle J.;Penninx, Brenda W.;Peters, Annette;Pramstaller, Peter P.;Raitakari, Olli T.;Rankinen, Tuomo;Rao, D. C.;Rice, Treva K.;Ridker, Paul M.;Ritchie, Marylyn D.;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J.;Saramies, Jouko;Sarzynski, Mark A.;Schwarz, Peter E. H.;Shuldiner, Alan R.;Staessen, Jan A.;Steinthorsdottir, Valgerdur;Stolk, Ronald P.;Strauch, Konstantin;Toenjes, Anke;Tremblay, Angelo;Tremoli, Elena;Vohl, Marie-Claude;Voelker, Uwe;Vollenweider, Peter;Wilson, James F.;Witteman, Jacqueline C.;Adair, Linda S.;Bochud, Murielle;Boehm, Bernhard O.;Bornstein, Stefan R.;Bouchard, Claude;Cauchi, Stephane;Caulfield, Mark J.;Chambers, John C.;Chasman, Daniel I.;Cooper, Richard S.;Dedoussis, George;Ferrucci, Luigi;Froguel, Philippe;Grabe, Hans-Joergen;Hamsten, Anders;Hui, Jennie;Hveem, Kristian;Joeckel, Karl-Heinz;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Maerz, Winfried;Munroe, Patricia B.;Njolstad, Inger;Oostra, Ben A.;Palmer, Colin N. A.;Pedersen, Nancy L.;Perola, Markus;Perusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E.;Saleheen, Danish;Sinisalo, Juha;Slagboom, P. Eline;Snieder, Harold;Spector, Tim D.;Thorsteinsdottir, Unnur R.;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, Andre G.;Uusitupa, Math;van der Harst, Pim;Veronesi, Giovanni;Walker, Mark;Wareham, Nicholas J.;Watkins, Hugh;Wichmann, H-Erich;Abecasis, Goncalo R.;Assimes, Themistocles L.;Berndt, Sonja I.;Boehnkes, Michael;Borecki, Ingrid B.;Deloukas, Panos;Franke, Lude;Frayling, Timothy M.;Groop, Leif C.;Hunter, David J.;Kaplan, Robert C.;O'Connell, Jeffrey R.;Qi, Lu;Schlessinger, David;Strachan, David P.;Stefansson, Kari;van Dujin, Cornelia M.;Willer, Cristen J.;Visscher, Peter M.;Yang, Jian;Hirschhorn, Joel N.;Zillikens, M. Carola;McCarthy, Mark I.;Speliotes, Elizabeth K.;North, Kari E.;Fox, Caroline S.;Barroso, Ines;Franks, Paul W.;Ingelsson, Erik;Heid, Iris M.;Loos, Ruth J. F.;Cupples, L. Adrienne;Morris, Andrew P.;Lindgren, Cecilia M.;Mohlke, Karen L.