PAR-1 for the course of neurodegeneration.
PAR-1 for the course of neurodegeneration.
复制标题
PAR-1 用于神经变性过程。
DOI：
10.1016/s0092-8674(04)00207-7
复制
发表时间：
2004
期刊：
影响因子：
64.5
通讯作者：
Fortini,MarkE
中科院分区：
文献类型：
--
作者：
Fortini,MarkE
The large number of kinases that phosphorylate the microtubule binding protein tau has posed a challenge to understanding their individual roles in turning this protein into a killer of neurons. A study in this issue ofCell(Nishimura et al., 2004) uses an elegant fusion of loss-of-function genetics and transgenic overexpression to make the case that the PAR-1 kinase stands at the head of a temporally ordered series of tau phosphorylations.
