Human metapneumovirus infections in young and elderly adults
Human metapneumovirus infections in young and elderly adults
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DOI：
10.1086/367901
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发表时间：
2003-03-01
影响因子：
6.4
通讯作者：
Walsh, EE
中科院分区：
文献类型：
--
作者：
Falsey, AR;Erdman, D;Walsh, EE
人偏肺病毒(HMPV)是一种新发现的呼吸道病原体，流行病学资料有限。在两个冬季，对年轻人和老年人进行了hMPV感染的前瞻性评估。在此期间因心肺疾病住院的患者也进行了研究。总体而言，984例疾病中有44例(4.5%)与hMPV感染有关，217名无症状受试者中有9例(4.1%)感染。第一年和第二年的HMPV患病率有显著差异(7/452[1.5%]比37/532[7.0%]；P<；.0001)。在第二年，11%的住院患者有hMPV感染的证据。感染发生在所有年龄段，但最常见的是年轻人。患有hMPV感染的虚弱老年人经常寻求医疗救治。总之，hMPV感染发生在所有年龄段的成年人中，可能在某些年份因呼吸道感染而住院的人中占很大比例。
Human metapneumovirus virus (hMPV) is a newly discovered respiratory pathogen with limited epidemiological data available. Cohorts of young and older adults were prospectively evaluated for hMPV infection during 2 winter seasons. Patients hospitalized for cardiopulmonary conditions during that period were also studied. Overall, 44 (4.5%) of 984 illnesses were associated with hMPV infection, and 9 (4.1%) of 217 asymptomatic subjects were infected. There was a significant difference in rates of hMPV illnesses between years 1 and 2 (7/452 [1.5%] vs. 37/532 [7.0%]; P < .0001). In the second year, 11% of hospitalized patients had evidence of hMPV infection. Infections occurred in all age groups but were most common among young adults. Frail elderly people with hMPV infection frequently sought medical attention. In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years.