Metabolism of murine TH 17 cells: Impact on cell fate and function.
Metabolism of murine TH 17 cells: Impact on cell fate and function.
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DOI：
10.1002/eji.201545788
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发表时间：
2016-04
影响因子：
5.4
通讯作者：
Solt LA
中科院分区：
文献类型：
--
作者：
Wang R;Solt LA
有效的适应性免疫应答依赖于淋巴细胞快速作用于各种感染性损伤的能力。在T淋巴细胞中，这种反应包括细胞生长、克隆扩增、分化和细胞因子产生，所有这些都对细胞造成显著的能量负担。因此，T细胞参与特定的代谢途径来执行其效应器功能。最近的见解表明，T细胞代谢重编程是适应性免疫反应的重要组成部分，特定的代谢途径决定了T细胞的命运决定，包括TH 17与T调节（Treg）细胞的发育。TH 17细胞自近十年前被发现以来，由于其在几种免疫介导的炎症性疾病的病理学中的作用而引起了人们的极大关注。对TH 17细胞进行全面表征的尝试已经证明，它们是高度动态的，根据环境线索调整其功能，这决定了细胞的代谢程序。在这篇简短的综述中，我们将重点介绍最近的数据，这些数据证明了细胞代谢对TH 17/Treg平衡的影响，并介绍了介导TH 17细胞代谢的因素。最后，我们讨论了潜在的治疗选择和调节TH 17细胞代谢治疗TH 17介导的疾病的影响。
An effective adaptive immune response relies on the ability of lymphocytes to rapidly act upon a variety of infectious insults. In T lymphocytes, this response includes cell growth, clonal expansion, differentiation, and cytokine production, all of which places a significant energy burden on the cell. As a result, T cells engage specific metabolic pathways to carry out their effector functions. Recent insights have demonstrated that T-cell metabolic reprogramming is an essential component of the adaptive immune response and specific metabolic pathways dictate T-cell fate decisions, including the development of TH17 versus T regulatory (Treg) cells. TH17 cells have garnered significant attention since their discovery nearly a decade ago due to their roles in the pathology of several immune-mediated inflammatory diseases. Attempts to fully characterize TH17 cells have demonstrated that they are highly dynamic, adjusting their function to environmental cues which dictates the metabolic program of the cell. In this short review, we will highlight recent data demonstrating the impact of cellular metabolism on the TH17/Treg balance and present factors that mediate TH17 cell metabolism. Finally, we discuss the potential therapeutic options and the implications of modulating TH17 cell metabolism for the treatment of TH17-mediated diseases.