Transient expression of S-100β immunostaining in developing thalamus and somatosensory cortex of rat
Transient expression of S-100β immunostaining in developing thalamus and somatosensory cortex of rat
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DOI：
10.1016/s0165-3806(03)00012-9
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发表时间：
2003-04-14
期刊：
影响因子：
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通讯作者：
Whitaker-Azmitia, PM
中科院分区：
文献类型：
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作者：
Muneoka, KT;Borella, A;Whitaker-Azmitia, PM
5-羟色胺被认为影响大鼠体感皮层中桶场的发育，并且已经报道了在相关丘脑（腹后）和皮层（顶叶的第IV层）区域中5-羟色胺转运体的瞬时表达以支持这一点。5-羟色胺的大部分发育作用是由神经营养蛋白S-100 β的释放介导的。因此，目前的工作进行，以确定S-100 β是否也显示在丘脑和桶场的瞬时表达模式。在出生后第1、7、15和22天，对雄性Sprague-Dawley大鼠进行免疫细胞化学检测S-100 β表达。S-100 β的表达在PD 7时选择性地在丘脑腹后核达到峰值，在PD 7至15时在顶叶皮质的第IV层达到峰值，呈“桶状”模式。我们的研究结果表明，S-100 β确实可能是5-羟色胺对桶场形成的影响的中介。(C)2003 Elsevier Science B. V.保留所有权利。
Serotonin is thought to affect the development of barrel fields in somatosensory cortex of rat and transient expression of the serotonin transporter has been reported in relevant thalamic (ventral posterior) and cortical (layer IV of parietal) regions in support of this. Much of the developmental role of serotonin is mediated by release of the neurotrophic protein S-100beta. The current work was thus undertaken to determine if S-100beta also shows a transient expression pattern in thalamus and barrel fields. Male Sprague-Dawley rats were examined immunocytochemically for S-100beta expression on postnatal days (PD) 1, 7, 15 and 22. Expression of S-100beta selectively peaked in the ventral posterior nucleus of the thalamus at PD 7, and in layer IV of the parietal cortex from PD 7 to 15, in a 'barrel-like' pattern. Our findings suggest that S-100beta could indeed be the mediator of serotonin's effects on barrel field formation. (C) 2003 Elsevier Science B.V. All rights reserved.