Use of laser phototherapy on a delayed wound healing of oral mucosa previously submitted to radiotherapy: case report
Use of laser phototherapy on a delayed wound healing of oral mucosa previously submitted to radiotherapy: case report
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DOI：
10.1111/j.1742-481x.2011.00788.x
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发表时间：
2011-08-01
影响因子：
3.1
通讯作者：
Magalhaes, Marina Gallottini
中科院分区：
文献类型：
--
作者：
Ramalho, Karen M.;Luiz, Ana C.;Magalhaes, Marina Gallottini
放射治疗对粘膜组织产生急性和延迟效应，干扰其愈合。本文报告一位曾接受放射线治疗的口腔黏膜伤口，以雷射光疗法治疗后，追踪三年，结果发现伤口愈合延迟。一位47岁的患者，6个月前接受了舌鳞状细胞癌的手术和放疗，手术区域出现肿块。活检显示残留聚乳糖缝线周围有慢性炎症浸润。2个月后，活检部位出现疼痛性粘膜裂开。使用波长为660 nm的半导体激光器（InGaAlP）和0.04 cm（2）的光斑尺寸进行LPT。应用的参数为40 mW，4 Jcm（2）/点，0.16 J/点，2.4 J/会话。在10个疗程中，通过接触模式在病变顶部和周围的15个点（4秒/点）进行准时照射。十次治疗后，伤口完全愈合。这种治疗被证明是保守和有效的，诱导愈合的慢性伤口的组织先前提交的放射治疗。
Radiotherapy produces both acute and delayed effects on mucosal tissues, disturbing their healing. This report shows a successful treatment with laser phototherapy (LPT) on a delayed wound healing in oral mucosa previously submitted to radiotherapy with a follow up of 3 years. A 47-year-old patient treated 6 months earlier for tongue squamous cell carcinoma by surgery and radiotherapy presented with a mass in the operated area. Biopsy showed chronic inflammatory infiltrate around a residual polyglactin suture. After 2 months there was a painful mucosal dehiscence on the biopsy site. LPT was performed using a semiconductor laser with 660-nm wavelength (InGaAlP) and spot size of 0.04 cm(2). The parameters applied were 40 mW, 4 Jcm(2)/point, 0.16 J/point, 2.4 J/session. The irradiation was performed punctually, through contact mode in 15 points (4 seconds/point), on top of and around the lesion, during ten sessions. The wound healed completely after ten sessions. This treatment proved to be conservative and effective, inducing healing of a chronic wound in a tissue previously submitted to radiotherapy.