A MODEL AT THE MACROSCOPIC SCALE OF PROSTATE TUMOR GROWTH UNDER INTERMITTENT ANDROGEN SUPPRESSION
A MODEL AT THE MACROSCOPIC SCALE OF PROSTATE TUMOR GROWTH UNDER INTERMITTENT ANDROGEN SUPPRESSION
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DOI：
10.1142/s021820250900408x
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发表时间：
2009-12
影响因子：
3.5
通讯作者：
Youshan Tao;Qian Guo;K. Aihara
中科院分区：
文献类型：
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作者：
Youshan Tao;Qian Guo;K. Aihara
肿瘤复发是前列腺癌激素治疗中的一个关键问题。所谓的雄激素非依赖性细胞被认为是这种复发的原因。这些细胞对雄激素抑制不敏感，但即使在雄激素缺乏的环境中也易于增殖。Bruchovsky等人在他们的实验和临床研究中表明，与持续雄激素抑制相比，间歇性雄激素抑制可延迟或预防复发。本文提出了一个模型，在宏观尺度上的前列腺肿瘤生长的间歇性雄激素抑制。定性分析表明，对于典型参数值，持续雄激素抑制无法避免肿瘤复发。数值模拟支持上述实验和临床建议，并暗示了间歇性雄激素抑制治疗的最佳给药方案。
The relapse of tumor is a crucial problem in hormonal therapy of prostate cancer. The so-called androgen-independent cells are considered to be responsible for such a recurrence. These cells are not sensitive to androgen suppression but rather apt to proliferate even in an androgen-poor environment. Bruchovsky et al. in their experimental and clinical studies suggested that intermittent androgen suppression may delay or prevent the relapse when compared with continuous androgen suppression. This paper proposes a model at the macroscopic scale of prostate tumor growth under intermittent androgen suppression. Qualitative analysis shows that the tumor relapse cannot be avoided under continuous androgen suppression for typical parameter values. Numerical simulation supports the above-mentioned experimental and clinical suggestion, and implies an optimal medication scheme of intermittent androgen suppression therapy.