POSTMENOPAUSAL BONE LOSS IS PREVENTED BY TREATMENT WITH LOW-DOSAGE ESTROGEN WITH CALCIUM
POSTMENOPAUSAL BONE LOSS IS PREVENTED BY TREATMENT WITH LOW-DOSAGE ESTROGEN WITH CALCIUM
复制标题
DOI：
10.7326/0003-4819-106-1-40
复制
发表时间：
1987-01-01
影响因子：
39.2
通讯作者：
CANN, CE
中科院分区：
文献类型：
--
作者：
ETTINGER, B;GENANT, HK;CANN, CE
73名妇女在绝经后立即进行了前瞻性骨量测量。通过比较三个骨骼部位的损失率，我们评估了单独给予钙补充剂或与低剂量雌激素治疗联合使用的保护效果。经过2年的随访，通过定量计算机断层扫描测量的脊柱骨小梁矿物质含量，在未经治疗的妇女中平均下降了9.0%(与基线相比，p=0.002)，在单独服用钙补充剂的妇女中，平均下降了10.5%(p=0.0001)。相比之下，每天服用0.3毫克结合雌激素和钙补充剂的女性仅有2.3%的轻微增长。没有接受治疗的女性和只接受钙治疗的女性的附件皮质骨骼出现了较小幅度的显著损失，但在接受雌激素和钙的女性中没有观察到显著的变化。
Bone mass was measured prospectively in 73 women during the period immediately after menopause. By comparing the rates of loss at three skeletal sites, we assessed the protective effects of calcium supplements given alone or combined with low-dosage estrogen therapy. After 2 years of follow-up, spinal trabecular mineral content, measured by quantitative computed tomography, decreased by a mean of 9.0% (p = 0.002 compared with baseline) in untreated women and a mean of 10.5% (p = 0.0001) in women given calcium supplements alone. By contrast, women given conjugated estrogens, 0.3 mg/d, with calcium supplements showed an insignificant increase of 2.3%. Significant losses of a lesser magnitude were seen in the appendicular cortical skeleton of women not receiving therapy and in those receiving calcium alone, but no significant changes were observed in women receiving estrogen with calcium.