Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy
Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy
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DOI：
10.1364/ol.33.001324
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发表时间：
2008-06-15
期刊：
影响因子：
3.6
通讯作者：
Chen, Zhongping
中科院分区：
文献类型：
--
作者：
Jung, Woonggyu;Tang, Suo;Chen, Zhongping
限制多光子显微镜（MPM）在临床和临床前研究中使用的一个因素是缺乏紧凑且灵活的探针。我们报告了一种采用微机电系统 (MEMS) 扫描镜和双包层光子晶体光纤 (DCPCF) 的小型化 MPM 探针。 MEMS反射镜和DCPCF的使用具有许多优点，例如尺寸减小、快速精确的扫描、短脉冲的高效传输以及荧光信号的高收集效率。完成的探针外径1厘米，长度14厘米。开发的探针集成到 MPM 系统中，用于对荧光珠、纸张和生物样本进行成像。 (C) 2008 年美国光学学会。
A factor that limits the use of multiphoton microscopy (MPM) in clinical and preclinical studies is the lack of a compact and flexible probe. We report on a miniaturized MPM probe employing a microelectromechanical system (MEMS) scanning mirror and a double-clad photonic crystal fiber (DCPCF). The use of a MEMS mirror and a DCPCF provides many advantages, such as size reduction, rapid and precise scanning, efficient delivery of short pulses, and high collection efficiency of fluorescent signals. The completed probe was 1 cm in outer diameter and 14 cm in length. The developed probe was integrated into an MPM system and used to image fluorescent beads, paper, and biological specimens. (C) 2008 Optical Society of America.