CHRONICALLY IMPLANTED POLAROGRAPHIC ELECTRODES
CHRONICALLY IMPLANTED POLAROGRAPHIC ELECTRODES
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DOI：
10.1152/jappl.1958.13.1.85
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发表时间：
1958-01-01
影响因子：
3.3
通讯作者：
FOX, RP
中科院分区：
文献类型：
--
作者：
CLARK, LC;MISRAHY, G;FOX, RP
绝缘金属极谱阴极被永久植入猫的大脑中，从而可以连续记录氧气的可用性。对电流与施加电位、阴极性质和大脑生理学变化的关系进行了研究。呼吸氧气时，平均氧气利用率增加约 2 倍；呼吸含有 14% 二氧化碳的空气时，平均氧气利用率增加 3 倍；而呼吸低氧气体混合物时，平均氧气利用率会降低。包括麻醉剂和升压剂在内的多种药物仅轻微改变大脑的氧气供应量，但似乎与二氧化碳张力的变化平行，并且乙醚和乙烯基醚会增加氧气供应量。植入阴极后一两天，波的频率为 6-12/分钟。并获得高达平均电流正负30%的幅度。它们的频率和振幅取决于温度，并且可以通过各种化学试剂改变。这些波与间隔距离超过几毫米的阴极异步。迄今为止的所有观察结果都与以下概念一致：这些波代表由于流经较细脑血管的血流的节律变化而导致阴极可用氧量的波动。
Insulated metal polarographic cathodes were permanently implanted in the brains of cats, allowing continuous recording of oxygen availability. A study was made of the current flow as related to applied potential, nature of the cathode and alterations in brain physiology. Mean oxygen availability increases about 2-fold on breathing oxygen, 3-fold on breathing air containing 14% carbon dioxide and decreases with hypoxic gas mixtures. The oxygen availability to the brain is only slightly altered by a wide variety of pharmacological agents, including anesthetics and pressor agents, but appears to parallel changes in carbon dioxide tension and to be increased by ethyl and vinyl ether. A day or two after implantation of a cathode, waves having a frequency of 6-12/min. and an amplitude of up to [plus or minus] 30% of the mean current are obtained. Their frequency and amplitude are temperature-dependent and can be altered by various chemical agents. The waves are asynchronous from cathodes spaced farther apart than a few millimeters. All the observations to date are consistent with the concept that these waves represent fluctuations in the amount of oxygen available at the cathode due to rhythmic variations in blood flow through the finer cerebral vessels.