INVOLVEMENT OF CAUDATE-PUTAMEN, GLOBUS PALLIDUS AND SUBSTANTIA NIGRA WITH NEUROLEPTIC AND CHOLINERGIC MODIFICATION OF LOCOMOTOR ACTIVITY
INVOLVEMENT OF CAUDATE-PUTAMEN, GLOBUS PALLIDUS AND SUBSTANTIA NIGRA WITH NEUROLEPTIC AND CHOLINERGIC MODIFICATION OF LOCOMOTOR ACTIVITY
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DOI：
10.1016/0028-3908(72)90017-2
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发表时间：
1972-01-01
影响因子：
4.7
通讯作者：
OLLEY, JE
中科院分区：
文献类型：
--
作者：
COSTALL, B;NAYLOR, RJ;OLLEY, JE
氟哌啶醇和槟榔碱均可抑制自发运动活动。两药联用仅具有加性作用。小剂量氟哌啶醇持续刺激活动。研究了尾状壳核、苍白球和黑质损伤对这些影响的改变。对双侧尾壳核损伤大鼠给予槟榔碱后，观察到刺激后的活动抑制，与假手术和对照动物相比，抑制作用明显降低。尾状壳核的损伤并没有改变氟哌啶醇对运动的影响。双侧黑质和白质病变后观察到明显的多动，茴香碱对抑郁非常敏感，氟哌啶醇对抑郁不敏感，氟哌啶醇的作用分别不变或消失。通过电极进入黑质可消除氟哌啶醇的刺激作用。将这些结果与先前的研究结果进行比较，有力地表明，自发运动活动减少的潜在机制与抗精神病药物和胆碱能药物产生猝倒的机制不同，因此反对药物的猝倒作用是其对运动活动的抑制作用的延伸的观点。
Both haloperidol and arecoline were shown to depress spontaneous motor activity. The effect of combining the two drugs was additive only. Small doses of haloperidol consistently stimulated activity. Modification of these effects by lesions in the caudate-putamen, globus pallidus and substantia nigra were studied.A depression of activity followed by stimulation was observed after the administration of arecoline to rats with bilateral lesions of the caudate-putamen, the depressant effect being significantly reduced as compared with that in sham-operated and control animals. Lesions of the caudate-putamen did not modify the locomotor effects of haloperidol.Marked hyperactivity observed after bilateral lesions of the substantia nigra and pallidum was highly susceptible to depression by arecoline but not by haloperidol, the effects of the latter drug being respectively unmodified or abolished. Passage of an electrode to the nigra abolished the stimulant effect of haloperidol.A comparison of these results with previous work strongly suggests that the underlying mechanisms involved in the reduction of spontaneous motor activity are not the same as those involved in the production of catalepsy by neuroleptic and cholinergic drugs and therefore opposes the idea that the cataleptic effect of a drug is the extension of its depressant effect upon locomotor activity.