CROSS-FAMILY DIMERIZATION OF TRANSCRIPTION FACTORS FOS JUN AND ATF CREB ALTERS DNA-BINDING SPECIFICITY
CROSS-FAMILY DIMERIZATION OF TRANSCRIPTION FACTORS FOS JUN AND ATF CREB ALTERS DNA-BINDING SPECIFICITY
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DOI：
10.1073/pnas.88.9.3720
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
CURRAN, T
中科院分区：
文献类型：
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作者：
HAI, T;CURRAN, T
转录因子Fos/Jun和ATF/CREB家族在将细胞外信号与特定靶基因表达的改变偶联中起作用。 与许多真核生物转录因子一样，这些蛋白质以二聚体形式与DNA结合。 二聚化由称为“亮氨酸拉链”基序的结构介导。 虽然Fos/Jun和ATF/CREB以前被认为优先与不同的DNA调控元件（AP-1/TRE和ATF/CRE位点，分别）相互作用，我们发现，这两个家庭的成员形成选择性的跨家庭异二聚体。 所得的异二聚体显示出彼此可区分的DNA结合特异性以及与它们的亲本同源二聚体的DNA结合特异性。 这些发现表明Fos/Jun和ATF/CREB家族的转录因子并不像以前认为的那样不同。 我们认为，它们可以被归类为一个转录因子超家族。
The Fos/Jun and ATF/CREB families of transcription factors function in coupling extracellular signals to alterations in expression of specific target genes. Like many eukaryotic transcription factors, these proteins bind to DNA as dimers. Dimerization is mediated by a structure known as the "leucine-zipper" motif. Although Fos/Jun and ATF/CREB were previously thought to interact preferentially with different DNA regulatory elements (the AP-1/TRE and ATF/CRE sites, respectively), we find that members of these two families form selective cross-family heterodimers. The resulting heterodimers display distinguishable DNA binding specificities from each other and from their parental homodimers. These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors.