POSITIONAL SIGNALING AND SPECIFICATION OF DIGITS IN CHICK LIMB MORPHOGENESIS
POSITIONAL SIGNALING AND SPECIFICATION OF DIGITS IN CHICK LIMB MORPHOGENESIS
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DOI：
10.1038/254199a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
WOLPERT, L
中科院分区：
文献类型：
--
作者：
TICKLE, C;SUMMERBELL, D;WOLPERT, L
位置信息的解释可以为肢体形态发生中的模式形成提供依据。相对于局部边界区域指定的沿着前后轴的位置信息沿着的梯度可以通过将该区域移植到沿着轴的连续位置沿着来修改。获得的数字的模式是一致的扩散的基础上的一个不稳定的形态的模型，因此类似于模型提出的模式在无脊椎动物的发展。
The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero–posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.