Bone mineral density in children and adolescents: Relation to puberty, calcium intake, and physical activity
Bone mineral density in children and adolescents: Relation to puberty, calcium intake, and physical activity
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DOI：
10.1210/jc.82.1.57
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发表时间：
1997-01-01
影响因子：
5.8
通讯作者：
KeizerSchrama, SMPFD
中科院分区：
文献类型：
--
作者：
Boot, AM;deRidder, MAJ;KeizerSchrama, SMPFD
对500名4-20岁儿童和青少年（205名男孩和295名女孩）的身高、体重、青春期、钙摄入量和体力活动与骨密度（BMD）的关系进行了评价。采用双能X线骨密度仪测量腰椎和全身骨密度（g/cm（2））。计算腰椎体积BMD以校正骨大小。BMD和体积BMD随年龄增长而增加。在青春期，年龄依赖性增量较高。校正年龄后，女孩的坦纳分期与所有三个BMD变量显著相关，男孩与脊柱BMD显著相关。在男孩中，经年龄调整后，BMD与钙摄入量和体力活动呈正相关。以体重、身高、坦纳分期、钙摄入量和体力活动作为决定因素并调整年龄的逐步回归分析得出了女孩坦纳分期和男孩体重的所有三个BMD变量的模型。BMD的主要独立决定因素是女孩的坦纳分期和男孩的体重。
The association of height, weight, pubertal stage, calcium intake, and physical activity with bone mineral density (BMD) was evaluated in 500 children and adolescents (205 boys and 295 girls), aged 4-20 yr. The BMD (grams per cm(2)) of lumbar spine and total body was measured with dual energy x-ray absorptiometry. Lumbar spine volumetric BMD was calculated to correct for bone size. BMD and volumetric BMD increased with age. During puberty, the age-dependent increment was higher. After adjustment for age, the Tanner stage was significantly associated with all three BMD variables in girls and with spinal BMD in boys. In boys, positive correlations were found between BMD and both calcium intake and physical activity after adjustment for age. Stepwise regression analysis with weight, height, Tanner stage, calcium intake, and physical activity as determinants with adjustment for age resulted in a model with Tanner stage in girls and weight in boys for all three BMD variables. The major independent determinant of BMD was the Tanner stage in girls and weight in boys.