Alzheimer's disease
Alzheimer's disease
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DOI：
10.1385/endo:22:2:113
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发表时间：
2003-11-01
期刊：
影响因子：
3.7
通讯作者：
Karbowiak, I
中科院分区：
文献类型：
--
作者：
Armanini, D;Vecchio, F;Karbowiak, I
阿尔茨海默氏病通常以血浆皮质醇增加为特征，但没有皮质亢进的临床证据。通过测量血浆皮质醇和硫酸脱氢表雄酮 (DHEAS)（通过酶免疫测定法）、单核白细胞中 I 型和 II 型皮质类固醇受体的数量（通过放射受体测定法）和淋巴细胞亚群（通过细胞荧光测定法），对 23 名连续的阿尔茨海默病患者和 23 名年龄和性别匹配的健康对照进行了研究。结果以中位数和范围表示。在阿尔茨海默病中，血浆皮质醇高于对照组（中位数 0.74，范围 0.47-1.21 vs 0.47，0.36-0.77 mmol/L；p < 0.001）。 AD 中的血浆 DHEAS、DHEAS/皮质醇比率以及 11 型皮质类固醇受体的数量显着低于对照组（DHEAS：中位数 1.81，范围 0.21-3.69 vs 3.51，1.35-9.07 μmol/L；DHEAS/皮质醇：2.04，范围 0.3-5.8 vs 6.8，范围2.7-24 和 11 型受体：每个细胞 1219、1000-2700 与 1950、10352750 个受体；p < 0.001）。荷尔蒙参数、年龄和简易测试分数之间没有发现相关性。这些数据支持阿尔茨海默病中肾上腺垂体轴失调的假设，这可能是皮质类固醇对靶组织损伤的结果。
Alzheimer's disease is often characterized by an increase in plasma cortisol without clinical evidence of hypercorticism. Twenty-three consecutive patients with Alzheimer's disease and 23 age- and sex-matched healthy controls were studied by measuring plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) (by enzyme immunoassay), the number of type I and type II corticosteroid receptors in mononuclear leukocytes (by radioreceptorassay), and the lymphocyte subpopulations (by cytofluorimetry). Results are expressed in terms of median and range. In Alzheimer's disease, plasma cortisol was higher than in controls (median 0.74, range 0.47-1.21 vs 0.47, 0.36-0.77 mmol/L; p < 0.001). Plasma DHEAS, the DHEAS/cortisol ratio, and the number of type 11 corticosteroid receptors were significantly lower in AD than in controls (DHEAS: median 1.81, range 0.21-3.69 vs 3.51, 1.35-9.07 μmol/L; DHEAS/ cortisol: 2.04, range 0.3-5.8 vs 6.8, range 2.7-24 and type 11 receptors: 1219, 1000-2700 vs 1950, 10352750 receptors per cell; p < 0.001). No correlation was found between the hormonal parameters, age, and minimental test score. These data support the hypothesis of a dysregulation of the adrenal pituitary axis in Alzheimer's disease, which is probably the consequence of damage to target tissues by corticosteroids.