DEGENERATIVE DISK DISEASE - ASSESSMENT OF CHANGES IN VERTEBRAL BODY MARROW WITH MR IMAGING
DEGENERATIVE DISK DISEASE - ASSESSMENT OF CHANGES IN VERTEBRAL BODY MARROW WITH MR IMAGING
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DOI：
10.1148/radiology.166.1.3336678
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发表时间：
1988-01-01
期刊：
影响因子：
19.7
通讯作者：
CARTER, JR
中科院分区：
文献类型：
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作者：
MODIC, MT;STEINBERG, PM;CARTER, JR
作者回顾了474例连续患者的腰椎MR成像。20例患者（4%）发现了1型改变（T1加权自旋回波图像上信号强度降低，T2加权图像上信号强度增加），77例患者（16%）发现了2型改变（T1加权图像上信号强度增加，T2加权图像上信号强度等或轻微增加）。在所有病例中，均有证据表明受累节段存在相关退行性椎间盘疾病。3例1型改变的组织学切片显示终板和血管化纤维组织破裂和裂开，而3例2型改变的组织学切片显示黄色骨髓替代。此外，纵向研究了16例MR记录终板变化的患者。在14个月至3年内，6名患者中有5名患者的1型改变转化为2型模式。10例患者的2型变化在2-3年内保持稳定。这些信号强度变化似乎反映了与退行性椎间盘疾病相关的椎体骨髓变化谱。
The authors reviewed magnetic resonance (MR) images of 474 consecutive patients referred for lumbar spine MR imaging. Type 1 changes (decreased signal intensity on T1-weighted spin-echo images and increased signal intensity on T2-weighted images) were identified in 20 patients (4%) and type 2 (increased signal intensity on T1-weighted images and isointense or slightly increased signal intensity on T2-weighted images) in 77 patients (16%). In all cases there was evidence of associated degenerative disk disease at the level of involvement. Histopathologic sections in three cases of type 1 change demonstrated disruption and fissuring of the end plates and vascularized fibrous tissue, while in three cases of type 2 change they demonstrated yellow marrow replacement. In addition, 16 patients with end-plate changes documented with MR were studied longitudinally. Type 1 changes in five of six patients converted to a type 2 pattern in 14 months to 3 years. Type 2 changes in ten patients remained stable over a 2-3-year period. These signal intensity changes appear to reflect a spectrum of vertebral body marrow changes associated with degenerative disk disease.