Type I interferons (alpha/beta) in immunity and autoimmunity.
Type I interferons (alpha/beta) in immunity and autoimmunity.
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DOI：
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发表时间：
2005
影响因子：
29.7
通讯作者：
A. Theofilopoulos;R. Baccala;B. Beutler;D. Kono
中科院分区：
文献类型：
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作者：
A. Theofilopoulos;R. Baccala;B. Beutler;D. Kono
I型干扰素（IFN-α/β）在生物学和医学中的重要性使得对其活性的研究与我们对正常和异常（自身）免疫应答的理解持续相关。这种相关性得到了以下发现的支持：在众多细胞因子中，明确确立IFN-α/β在定义先天性和适应性免疫过程的定性和定量特征中占主导地位。阐明这些关键细胞因子的生物学的最新进展包括更好地定义其复杂的信号传导通路，确定其在修改其他细胞因子的作用中的重要性，Toll样受体在其诱导中的作用，其主要的细胞生产者，以及其对细胞和体液免疫应答的广泛和多样的影响。因此，IFN-α/β在自身免疫发病机制中的作用仍然处于科学研究的前沿，并已开始阐明这些分子促进或抑制全身性和器官特异性自身免疫疾病的机制。
The significance of type I interferons (IFN-alpha/beta) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-alpha/beta, among the multitude of cytokines, as dominant in defining qualitative and quantitative characteristics of innate and adaptive immune processes. Recent advances elucidating the biology of these key cytokines include better definition of their complex signaling pathways, determination of their importance in modifying the effects of other cytokines, the role of Toll-like receptors in their induction, their major cellular producers, and their broad and diverse impact on both cellular and humoral immune responses. Consequently, the role of IFN-alpha/beta in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases.