Quality-based pharmacokinetic model selection on DCE-MRI for characterizing orbital lesions
Quality-based pharmacokinetic model selection on DCE-MRI for characterizing orbital lesions
复制标题
DOI：
10.1002/jmri.26747
复制
发表时间：
2019-11-01
影响因子：
4.4
通讯作者：
Fournier, Laure
中科院分区：
文献类型：
--
作者：
Lecler, Augustin;Balvay, Daniel;Fournier, Laure
背景虽然有几项研究评价了动态对比增强（DCE）MRI在眼眶中的应用，显示了其在检测和诊断眼眶病变时的实用性，但没有一项研究评价了药代动力学模型。目的为3.0T动态增强磁共振成像（DCE-MRI）评价眼眶病变提供基于质量的药代动力学模型选择。研究类型前瞻性。人群从2015年12月至2017年4月，151例眼眶病变患者在手术前接受了MRI，包括高时间分辨率DCE序列，分为一个训练数据集和一个测试数据集，分别有100例和51例患者。场强/序列3 T/DCE。评估测试了六种不同的药代动力学模型。使用Wilcoxon-2样本检验和逻辑回归进行单变量和多变量分析，以比较整个队列的每个药代动力学模型的恶性和良性肿瘤之间的参数。对训练数据集进行受试者工作特征（ROC）曲线分析，以确定每个药代动力学模型的曲线下面积（AUC）和最佳截止值，然后对测试数据集进行验证，以计算灵敏度、特异性和准确度。结果无论哪种模型，恶性病变的组织血流量和组织血容量值均显著高于良性病变：103.8-195.1 vs. 65-113.8，P [0.05]。
Background Although several studies have evaluated dynamic contrast-enhanced (DCE) MRI in the orbit, showing its utility when detecting and diagnosing orbital lesions, none have evaluated the pharmacokinetic models. Purpose To provide a quality-based pharmacokinetic model selection for characterizing orbital lesions using DCE-MRI at 3.0T. Study Type Prospective. Population From December 2015 to April 2017, 151 patients with an orbital lesion underwent MRI prior to surgery, including a high temporal resolution DCE sequence, divided into one training and one test dataset with 100 and 51 patients, respectively. Field Strength/Sequence 3T/DCE. Assessment Six different pharmacokinetic models were tested. Statistical Tests Univariate and multivariate analyses were performed using Wilcoxon-2-sample tests and a logistic regression to compare parameters between malignant and benign tumors for each pharmacokinetic model for the whole cohort. Receiver operating characteristic (ROC) curve analyses were performed on the training dataset to determine area under curve (AUC) and optimal cutoff values for each pharmacokinetic model, then validated on the test dataset to calculate sensitivity, specificity, and accuracy. Results Regardless of the model, tissue blood flow and tissue blood volume values were significantly higher in malignant vs. benign lesions: 103.8-195.1 vs. 65-113.8, P [