HLA polymorphism in six Malay subethnic groups in Malaysia
HLA polymorphism in six Malay subethnic groups in Malaysia
复制标题
DOI：
10.1016/j.humimm.2009.04.003
复制
发表时间：
2009-07-01
期刊：
影响因子：
2.7
通讯作者：
Norazmi, Mohd-Nor
中科院分区：
文献类型：
--
作者：
Edinur, Hisham Atan;Zafarina, Zainuddin;Norazmi, Mohd-Nor
在这项研究中，人类白细胞抗原（HLA）I类和11类通过序列特异性引物分型在176个无关的个人从马来西亚半岛的6个马来亚族群：吉兰丹（n = 25），米南卡堡（34），爪哇（30），武吉士（31），班贾尔（33），和拉瓦（23）。所有组中最常见的HLA等位基因为A*24（26-41%）、Cw*07（24-32%）、B*15（22-30%）、DRB 1 *12（15-36%）和DQB 1 *03（25-51%）。研究的马来亚族群表现出密切的关系，彼此和其他亚洲人口，尽管他们之间的具体差异。班贾尔人、武吉士人和爪哇马来人之间没有明显的差异，这可能是由于他们来自爪哇海周围的岛屿。这三个马来人亚种族群体随后被合并为一个群体，这也有助于增加样本数量和提高统计结果。米南卡保和拉瓦马来人在等位基因组和单倍型频率上表现出很高的相似性，这可能是他们共同起源于苏门答腊的结果。吉兰丹马来人，除了与其他群体相比具有统计学显著性差异外，还表现出最常见的单倍型差异，这在其他亚种族群体中几乎不存在。(C)2009年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
In this study, human leukocyte antigen (HLA) class I and 11 were examined through sequence-specific primer typing in 176 unrelated individuals from six Malay subethnic groups of Peninsular Malaysia: Kelantan (n = 25), Minangkabau (34),Jawa (30), Bugis (31), Banjar (33), and Rawa (23). The most common HLA alleles in all groups were A*24 (26-41%), Cw*07 (24-32%), B*15 (22-30%), DRB1*12 (15-36%), and DQB1*03 (25-51%). The Malay subethnic groups studied demonstrated a close relationship to each other and to other Asian populations, despite specific differences between them. Banjar, Bugis, and Jawa Malays demonstrated no significant difference from each other, which could be a result of their related origin from the islands around the Java Sea. These three Malay subethnic groups were then collapsed into one group, which also helped to increase the sample number and sharpen statistical results. Minangkabau and Rawa Malays exhibited high similarities in allele group and haplotype frequencies, which could be a consequence of their common origin from Sumatera. Kelantan Malays, in addition to their statistically significant differences compared with the other groups, also exhibited differences on the most frequent haplotypes, which are almost absent in the other subethnic groups studied. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.